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Products >  Cell_Biology >  Cell_Adhesion_and_Extracellular_Matrix >  Antibodies_A_C >  Claudin-7_Mouse_Rat

Anti-Mouse/Rat Claudin-7 (C) Rabbit IgG Antibody

Claudins are a family of proteins that control the flow of molecules in the intercellular space between epithelial cells. They are the most important components of tight junctions--a form of cell-to-cell adhesion that forms continuous seals around cells. Tight junctions act as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Claudins have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Over 24 members of the claudin family have been identified in humans. In mouse, claudin-1, -2, -6, -7, and -15 are expressed at high levels in liver and kidney, while claudin-5 is expressed in vascular endothelial cells. Differential expression of the human CLDN7 gene has been associated with breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, and thyroid cancer. Claudin-7 is expressed constitutively in the mammary epithelium throughout development, and is essential for NaCl homeostasis in distal nephrons. It is also known as clostridium perfringens enterotoxin receptor-like 2 (CPETRL2) and CEPTRL2.

This product is an affinity-purified IgG antibody that recognizes mouse/rat claudin-7 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, and immunocytochemical (ICC) detection of mouse/rat claudin-7 protein.

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Features

  • Cat.#: 18875A, 18875B
  • Target Name: Mouse/rat claudin-7 protein
  • Antigen: Mouse/rat claudin-7 C-terminal synthetic peptide
  • Application: WB, IHC, ICC
  • Specificity: Reacts with claudin-7; does not cross-react with claudins 1-6, 8, 12, or 15
  • Target Entrez Gene ID: 53624, 65132

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1 µg/mL
  • Immunohistochemical/immunocytochemical techniques: 5–7 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

clostridium perfringens enterotoxin receptor-like 2, CPETRL2, CEPTRL2




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
18875A Anti-Mouse/Rat Claudin-7 (C) Rabbit IgG Affinity Purify 10 ug $113.00 *
  18875B Anti-Mouse/Rat Claudin-7 (C) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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