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Products >  Cell_Biology >  Cell_Adhesion_and_Extracellular_Matrix >  Antibodies_A_C >  Claudin-6_Mouse

Anti-Mouse Claudin-6 (C) Rabbit IgG Antibody

Claudins are integral membrane proteins and components of tight junction strands, which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Tight junction strands also play critical roles in maintaining cell polarity and signal transductions. In humans, 24 claudin superfamily members have been identified. Claudin 6 is essential for blastocyst formation in preimplantation mouse embryos, and for the formation and maintenance of the epidermal permeability barrier. It is also known as skullin and AL024037. Claudin-6 has been identified as a novel diagnostic marker for primitive germ cell tumors, and other tumors with primitive phenotypes. Expression of claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas.

This product is an affinity-purified IgG antibody that recognizes human claudin-6 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human claudin-6 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18865A
  • Target Name: Mouse claudin-6 protein
  • Antigen: Human claudin-6 C-terminal synthetic peptide
  • Application: WB, IHC
  • Specificity: Does not cross-react with other claudin superfamily proteins
  • Target Entrez Gene ID: 54419

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1 µg/mL
  • Immunohistochemical techniques: 5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Skullin, AL024037




 
 
Products
Cat. # Product Package Size Price # of Units Select
18865A Anti-Mouse Claudin-6 (C) Rabbit IgG Affinity Purify 100 ug $499.00
 

 


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