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Products >  Cell_Biology >  Cell_Adhesion_and_Extracellular_Matrix >  Antibodies_A_C >  Claudin-15_Mouse_Antibody

Anti-Mouse Claudin-15 (C) Rabbit IgG Antibody

Claudins are a family of proteins that control the flow of molecules in the intercellular space between epithelial cells. They are the most important components of tight junctions--a form of cell-to-cell adhesion that forms continuous seals around cells. Tight junctions act as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Claudins have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Over 24 members of the claudin family have been identified in humans. In mouse, claudin-1, -2, -6, -7, and -15 are expressed at high levels in liver and kidney, while claudin-5 is expressed in vascular endothelial cells. Claudin 15 deficiency is associated with decreased intestinal epithelial paracellular ion permeability. The CLDN15 gene is a direct target for hepatocyte-nuclear-factor-4alpha (HNF4-alpha), and CLDN15 expression is downregulated in inflammatory bowel disease. Claudin-15 is also known as BB107105 and 2210009B08Rik.

This product is an affinity-purified IgG antibody that recognizes mouse claudin-15 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, and immunocytochemical (ICC) detection of mouse claudin-15 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18805A, 18805B
  • Target Name: Mouse claudin-15 protein
  • Antigen: Mouse claudin-15 C-terminal synthetic peptide
  • Application: WB, IHC, ICC
  • Specificity: Reacts with claudin-15; does not cross-react with claudins 1-8 or 12
  • Target Entrez Gene ID: 60363

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 5 µg/mL
  • Immunohistochemical/immunocytochemical techniques: 5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

BB107105, 2210009B08Rik




 
 
Products
Cat. # Product Package Size Price # of Units Select
18805A Anti-Mouse Claudin-15 (C) Rabbit IgG Affinity Purify 10 ug $113.00 *
18805B Anti-Mouse Claudin-15 (C) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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