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Products >  Cell_Biology >  Cancer_and_Inflammation >  Proteins >  CEA_Human_Proteins

Human CEA

Carcinoembryonic antigen (CEA) is a glycosyl phosphatidyl inositol (GPI)-cell surface anchored glycoprotein, first identified in tissue extracts from human colon tumors. The CEA family of genes is part of the immunoglobulin superfamily. In humans, the CEA family consists of 29 genes, 18 of which are normally expressed only during fetal development. Therefore, CEA is not detectable in the blood of healthy adults, but CEA expression is observed in many types of cancer.

The measurement of CEA levels has been used in diagnostic tests for colorectal carcinoma, gastric carcinoma, pancreatic carcinoma, lung carcinoma and breast carcinoma, and to detect cancer recurrence after surgical removal of tumors. CEA levels are also elevated in other disease, like ulcerative colitis, pancreatitis, cirrhosis, COPD, and Crohn's disease, as well as in smokers.

  At-A-Glance   Documents

Features

  • Origin: Human gastric cancer cell line (MKN-45) supernatant
  • Purity: Purified by liquid chromatography. Immunological cross-reactive proteins such as nonspecific cross-reacting antigen (NCA) are removed by affinity purification.

Applications

  • Control experiments for detection of human CEA

Storage

Lyophilized: 2–8°C. Solution: –20°C.

Form

Lyophilized from solution in PBS. To use, reconstitute in 0.1 mL H2O.


 
Products
Cat. # Product Contents Size Price Units Select
50010A Human CEA 0.1 mg $1,103.00 *
50010B Human CEA 1 mg $7,781.00 *
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 

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