Leucine-rich alpha2-glycoprotein 1 (LRG1; also known as LRG or HMFT1766) was first identified as a trace component in human serum. LRG1 contains a 24 amino-acid consensus sequence, the leucine-rich repeat (LRR), that is found in a large family of proteins. LRG is expressed in primary human neutrophils, and its expression is upregulated during neutrophilic granulocyte differentiation of human and murine cell lines. High levels of LRG1 have been reported in the cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus (iNPH), and LRG1 measurement can be useful to distinguish iNPH from Alzheimer's disease symptoms.
These kits are solid-phase sandwich ELISAs using two antibodies that are highly specific to human, mouse, or rat LRG1 protein; one is precoated on the ELISA plate and the other is HRP-conjugated. These kits can be used to measure soluble human or mouse LRG1 protein in serum, EDTA plasma, urine, or cerebrospinal fluid.