Lectins are sugar-binding proteins that play a role in biological recognition of specific sugar-containing molecules. Human intelectin-1 (encoded by the ITLNI gene) was first identified by its binding to galactofuranosyl residues. Intelectin-1 functions as a receptor for both bacterial arabinogalactans and lactoferrin. It has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Recently, it was found that intelectin-1 may be a useful molecular marker for epithelioid-type malignant pleural mesotheliomas (MPMs).
This kit is a solid-phase sandwich ELISA using two antibodies that are highly specific to human intelectin-1 protein; one is precoated on the ELISA plate and the other is HRP-conjugated. This assay kit can be used to measure soluble human intelectin-1 protein in serum, heparin plasma, or cell culture supernatants.