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Products >  Cell_Biology >  Cancer_and_Inflammation >  Antibodies_T-Z >  YB-1_Human_Monoclonal

Anti-Human YB-1 (21A3) Mouse IgG MoAb

Y-box binding protein 1 (YB-1) is encoded by the YBX1 gene in humans. It binds to splice sites in pre-mRNA, regulates splice site selection, and stabilizes cytoplasmic mRNA. YB-1 acts as a transcriptional regulator by: i) controlling the interaction between eukaryotic translation initiation factors and mRNA; and ii) binding to the Y-box motif found in the promoters of genes such as multidrug resistance 1 (MDR1) and HLA class II genes. YB-1 gene expression has been associated with lung cancer and the response to chemotherapy in patients with breast cancer. YB-1 is also known as nuclease sensitive element binding protein 1 (NSEP1), enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B (DBPB), Y-box transcription factor, BP-8, CSDA2, CSDB1, and MDR-NF1.

This product is an affinity-purified IgG antibody that recognizes human YB-1 protein. The antibody was raised in mouse using recombinant YB-1 protein and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human YB-1 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 11106A, 11106B
  • Target Name: Human YB-1 protein
  • Antigen: Human YB-1 recombinant protein
  • Application: WB, IHC
  • Target Entrez Gene ID: 4904

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1 µg/mL
  • Immunohistochemical techniques: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 0.5 mL H2O.

Alternative names

Y-box binding protein 1, YBX1, nuclease sensitive element binding protein 1, NSEP1, enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B, DBPB, Y-box transcription factor, BP-8, CSDA2, CSDB1, MDR-NF1




 
 
Products
Cat. # Product Package Size Price # of Units Select
11106A Anti-Human YB-1 (21A3) Mouse IgG MoAb 10 ug $113.00 *
11106B Anti-Human YB-1 (21A3) Mouse IgG MoAb 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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