Home Takara Clontech Logo Takara Clontech
login | register | order now | view cart | feedback
Products
Cell Biology


Products >  Cell_Biology >  Cancer_and_Inflammation >  Antibodies_T-Z >  TSC1-Hamartin_Human

Anti-Human TSC1/Hamartin (T1149) Rabbit IgG Antibody

The tuberous sclerosis 1 (TSC1) gene in humans encodes a peripheral membrane protein also known as hamartin, TSC, LAM, and KIAA0243. TSC1 complexes with TSC2 (tuberin) and stabilizes it. The TSC1/TSC2 complex inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (EIF4BP1) and ribosomal protein S6 kinase (S6K1), by negatively regulating signaling in the mammalian target of rapamycin complex 1 (mTORC1). Mutations in the TSC1 gene are associated with the development of tuberous sclerosis.

This product is an affinity-purified IgG antibody that recognizes human TSC1 protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human TSC1 protein.

  At-A-Glance   Documents   Images & Data

Features

  • Cat.#: 28017A, 28017B
  • Target Name: Human TSC1 protein
  • Antigen: Human TSC1 synthetic peptide
  • Specificity: Cross-reacts with mouse TSC1
  • Application: WB, IHC
  • Target Entrez Gene ID: 7248

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL
  • Immunohistochemical techniques: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Hamartin, TSC, LAM, KIAA0243




 
 
Products
Cat. # Product Contents Size Price Units Select
28017A Anti-Human TSC1/Hamartin (T1149) Rabbit IgG Affinity Purify 10 ug $113.00 *
28017B Anti-Human TSC1/Hamartin (T1149) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

Clontech is a Takara Bio Company © 2014 Privacy Policy | Terms & Conditions