Niban belongs to a group of related proteins encoded by the FAM129 gene family in humans. It was originally cloned from a rat cancer cell line. Niban controls the phosphorylation of several transcriptional regulatory factors, including EIF2A, EIF4EBP1, and RPS6KB1. Niban protein is expressed in various types of thyroid tumors but not in normal thyroid tissue. High levels of Niban expression have been reported in heart, skeletal muscle, pancreas, white blood cells, and prostate; with moderate expression in colon and spleen. Niban is thought to be involved in the endoplasmic reticulum stress response. Niban is also known as family with sequence similarity 129, member A; chromosome 1 open reading frame 24 (C1orf24), cell growth-inhibiting gene 39 protein (GIG39), and protein FAM129A.
These products are affinity-purified IgG antibodies that recognize human and rat Niban protein. The antibodies were raised in rabbit or mouse using recombinant protein or a synthetic peptide and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human and rat Niban protein.