Novel Aspartic Proteinase of the PepSIN Family (Napsin A, or NAPSA) belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. It is also known as aspartyl protease 4 (ASP4), KAP, Kdap, napsin-1, NAP1, NAPA, and SNAPA. Two closely related proteins are known, Napsin A and Napsin B. Napsin A is a single-chain, 38 kDa protein. It is expressed at high levels in human lung and kidney, and at lower levels in spleen. Napsin A expression has been detected in type II pneumocytes and in lung adenocarcinomas.
This product is an affinity-purified IgG antibody that recognizes human Napsin A protein. The antibody was raised in mouse using a synthetic peptide and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human Napsin A protein, especially in lung adenocarcinomas.