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Products >  Cell_Biology >  Cancer_and_Inflammation >  Antibodies_H-N >  KDR_Human

Anti-Human KDR IgG Antibody

Kinase insert domain receptor (KDR) is one of two main receptors for vascular endothelial growth factor (VEGF). KDR is a type III receptor tyrosine kinase that is the main mediator of VEGF-induced proliferation, survival, migration, and differentiation in endothelial cells. KDR is also known as fetal liver kinase 1 (Flk1), protein-tyrosine kinase receptor flk-1, vascular endothelial growth factor receptor 2 (VEGFR2), CD309, and tyrosine kinase growth factor receptor. Binding of VEGFA, VEGFC, or VEGFD to KDR initiates several signaling cascades, including pathways that involve protein kinase C (PKC), mitogen-activated protein (MAP) kinases, and AKT1 kinase. Mutations in the KDR gene are associated with infantile capillary hemangiomas.

These products are affinity-purified IgG antibodies that recognize human KDR protein. The antibodies were raised in rabbit or mouse using recombinant KDR protein or a synthetic peptide, and can be used for Western blot (WB) detection, immunoprecipitation (IP), neutralization assay (NT), or flow cytometry (FCM) of human KDR protein.

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Features

  • Cat.#: 10347A, 10347B
  • Target Name: Human KDR protein
  • Antigen: Human KDR (extracellular domain) recombinant protein
  • Application: WB, IP, FCM
  • Target Entrez Gene ID: 3791

  • Cat.#: 10347F
  • Target Name: Human KDR protein
  • Antigen: Human KDR (extracellular domain) recombinant protein
  • Application: NT
  • Target Entrez Gene ID: 3791

  • Cat.#: 18435A, 18435B
  • Target Name: Human KDR protein
  • Antigen: Human KDR C-terminal synthetic peptide
  • Application: WB
  • Target Entrez Gene ID: 3791

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL (Cat.# 10347); 2–5 µg/mL (Cat.# 18435)
  • Immunoprecipitation: 3–5 µg per reaction
  • Neutralization assay: 10 µg/mL
  • Flow cytometry: 0.1–0.5 µg (per 1 x 105 cells)

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.*

*NOTE: Cat.# 10347F is supplied frozen without BSA or NaN3.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).*

Alternative names

Fetal liver kinase 1, Flk1, protein-tyrosine kinase receptor flk-1, vascular endothelial growth factor receptor 2, VEGFR2, CD309, tyrosine kinase growth factor receptor




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
10347A Anti-Human KDR (23B31) Mouse IgG MoAb 10 ug $113.00 *
  10347B Anti-Human KDR (23B31) Mouse IgG MoAb 100 ug $499.00
  10347F Anti-Human KDR (23B31) Mouse IgG MoAb (Frozen) 100 ug $499.00
  18435A Anti-Human KDR (C) Rabbit IgG Affinity Purify 10 ug $113.00 *
  18435B Anti-Human KDR (C) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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