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Products >  Cell_Biology >  Cancer_and_Inflammation >  Antibodies_A-G >  c-Ret_Human

Anti-Human c-Ret Rabbit IgG Antibody

The RET ("rearranged during transfection") proto-oncogene encodes a receptor tyrosine kinase also known as cadherin family member 12 (CDHF12), cadherin-related family member 16 (CDHR16), Hirschsprung disease 1, PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, and RET-ELE1. Alternative splicing of the RET gene results in three isoforms of the Ret protein. These contain 51, 43, and 9 amino acids in their C-terminal sections and are designated Ret-51, Ret-43, and Ret-9, respectively. The extracellular domain of Ret protein contains a cadherin-like domain and several N-terminal glycosylation sites. The fully glycosylated Ret protein is reported to have a molecular weight of 170 kDa; other isoforms are reported as 150 kDa and 190 kDa. The RET gene plays an essential role in neural crest development. Mutations in the RET gene are associated with several types of endocrine neoplasia, Hirschsprung disease, and medullary thyroid carcinoma.

These products are affinity-purified IgG antibodies that recognizes human c-Ret long isoform (Cat.# 18128) and C-terminus (Cat.# 18121). The antibodies were raised in rabbit using synthetic c-Ret peptides, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human c-Ret proteins.

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Features

  • Cat. #: 18121A, 18121B
  • Target Name: Human c-Ret protein
  • Antigen: Human c-Ret C-terminal synthetic peptide
  • Clone: R787
  • Application: IHC, WB
  • Specificity: Cross-reacts with mouse and rat c-Ret
  • Target Entrez Gene ID: 5979

  • Cat.#: 18128A, 18128B
  • Target Name: Human c-Ret protein (long isoform)
  • Antigen: Human c-Ret (long isoform) C-terminal synthetic peptide
  • Application: WB, IP
  • Specificity: Specific to long isoform of human c-Ret; species cross-reactivity n/a
  • Target Entrez Gene ID: 5979

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Immunohistochemical techniques: 2–5 µg/mL
  • Western blot: 2–5 µg/mL
  • Immunoprecipitation: 3–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration, 100 µg/mL).

Alternative names

cadherin family member 12 (CDHF12), cadherin-related family member 16 (CDHR16), Hirschsprung disease 1, PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, RET-ELE1




 
 
Products
Cat. # Product Contents Size Price Units Select
18121A Anti-Human c-Ret (R787) Rabbit IgG Affinity Purify 10 ug $113.00 *
18121B Anti-Human c-Ret (R787) Rabbit IgG Affinity Purify 100 ug $499.00
18128A Anti-Human c-Ret (Long Isoform) Rabbit IgG Affinity Purify 10 ug $113.00 *
18128B Anti-Human c-Ret (Long Isoform) Rabbit IgG Affinity Purify 200 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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