The c-Met proto-oncogene encodes a protein known as hepatocyte growth factor receptor (HGFR). HGFR is also known as RCCP2, scatter factor (SF) receptor, HGF/SF receptor, and AUTS9. HGFR possesses tyrosine-kinase activity. The HGFR precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are linked by disulfide bonds to form the mature HGFR protein. Abnormal expression of c-Met results in tumor growth, angiogenesis, and metastasis.
These products are affinity-purified IgG antibodies that recognize human HGFR protein. The antibodies were raised in rabbit using synthetic peptides and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human HGFR or phosphorylated HGFR (Tyr1235).