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Products >  Cell_Biology >  Cancer_and_Inflammation >  Antibodies_A-G >  Girdin_Human

Anti-Human Girdin Rabbit IgG Antibody

GIRDers of actIN filament (Girdin) belongs to a family of proteins characterized by the presence of a coiled-coil domain. Girdin is an actin-binding protein that is activated by the serine/threonine kinase Akt. Girdin is a key modulator of the AKT-mTOR signaling pathway that controls the timing of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development, and synapse formation. It also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors (GPCRs). Elevated levels of Girdin expression are associated with cancer metastasis. Girdin is also known as coiled-coil domain containing 88A (CCDC88A), G alpha-interacting vesicle-associated protein, Hook-related protein 1, Akt-phosphorylation enhancer (APE), GIV, GRDN, HkRP1, and KIAA1212.

These products are affinity-purified IgG antibodies that recognize human Girdin protein. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, immunocytochemical (ICC) detection, or immunoprecipitation (IP) of human Girdin protein.

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Features

  • Cat.#: 18979A, 18979B
  • Target Name: Human Girdin protein
  • Antigen: Human Girdin synthetic peptide
  • Application: WB, ICC, IP
  • Target Entrez Gene ID: 55704

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2.5 µg/mL (Cat.# 18979)
  • Immunohistochemical techniques: 1–2 µg/mL
  • Immunocytochemical techniques: 6–12 µg/mL
  • Immunoprecipitation: 1–10 µg per reaction

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Coiled-coil domain containing 88A, CCDC88A, G alpha-interacting vesicle-associated protein, Hook-related protein 1, Akt-phosphorylation enhancer, APE, GIV, GRDN, HkRP1, KIAA1212




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
18979A Anti-Human Girdin Rabbit IgG Affinity Purify 10 ug $113.00 *
  18979B Anti-Human Girdin Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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