Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein that may function as a cell adhesion protein. It is also known as CAK1 antigen and soluble MPF mesothelin-related protein (SMRP). Mesothelin is digested in vivo by a furin-like protease to yield fragments approximately 31 kD and 40 kD. In humans, mesothelin is overexpressed in epithelial mesotheliomas, ovarian cancers, and in some types of squamous cell carcinomas. Alternative splicing results in multiple mesothelin variants. The ERC (expressed in renal carcinoma) gene, which was identified in a rat model of renal cancer, has been proposed as a homolog of the human MSLN gene.
These products are affinity-purified IgG antibodies that recognizes the C-ERC/Mesothelin (40 kD fragment) of mouse and rat mesothelin protein. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection and immunohistochemical (IHC) detection of mesothelin.