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Products >  Cell_Biology >  Cancer_and_Inflammation >  Antibodies_A-G >  C-ERC_Mesothelin

C-ERC/Mesothelin Antibody

Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein that may function as a cell adhesion protein. It is also known as CAK1 antigen and soluble MPF mesothelin-related protein (SMRP). Mesothelin is digested in vivo by a furin-like protease to yield fragments approximately 31 kD and 40 kD. In humans, mesothelin is overexpressed in epithelial mesotheliomas, ovarian cancers, and in some types of squamous cell carcinomas. Alternative splicing results in multiple mesothelin variants. The ERC (expressed in renal carcinoma) gene, which was identified in a rat model of renal cancer, has been proposed as a homolog of the human MSLN gene.

These products are affinity-purified IgG antibodies that recognizes the C-ERC/Mesothelin (40 kD fragment) of mouse and rat mesothelin protein. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection and immunohistochemical (IHC) detection of mesothelin.

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Features

  • Cat.#: 28001A, 28001B
  • Target Name: Rat mesothelin
  • Antigen: Rat C-ERC/Mesothelin synthetic peptide
  • Application: WB, IHC
  • Target Entrez Gene ID: 60333

  • Cat.#: 28127A, 28127B
  • Target Name: Mouse mesothelin
  • Antigen: Mouse C-ERC/Mesothelin synthetic peptide
  • Application: WB, IHC
  • Target Entrez Gene ID: 60333

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 0.1–2.0 µg/mL (Cat.# 28001); 1.0 µg/mL (Cat.# 28127)
  • Immunohistochemical techniques: 0.2–5.0 µg/mL (Cat.# 28001); 0.3–1.0 µg/mL (Cat.# 28127)

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

CAK1 antigen, soluble MPF mesothelin-related protein, SMRP




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
28001A Anti-Rat C-ERC/Mesothelin (306) Rabbit IgG Affinity Purify 10 ug $113.00 *
28001B Anti-Rat C-ERC/Mesothelin (306) Rabbit IgG Affinity Purify 100 ug $499.00
28127A Anti-Mouse C-ERC/Mesothelin (308) Rabbit IgG Affinity Purify 5 ug $114.00 *
28127B Anti-Mouse C-ERC/Mesothelin (308) Rabbit IgG Affinity Purify 50 ug $525.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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