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Products >  Cell_Biology >  Cancer_and_Inflammation >  Antibodies_A-G >  Bcl-1_Cyclin_D1_Monoclonal

Anti-Human Bcl-1/Cyclin D1 (5D4) Mouse IgG MoAb

The protein encoded by the Bcl-1 oncogene, known as cyclin D1, belongs to the highly conserved family of cyclin-dependent kinase (CDK) regulators. It is also known as CCND1, B-cell lymphoma 1 protein (BCL1), parathyroid adenomatosis 1 (PRAD1), B-cell CLL/lymphoma 1, G1/S-specific cyclin-D1, D11S287E, and U21B31. Different cyclins exhibit distinct expression and degradation patterns that contribute to the coordination of the cell cycle during mitosis. Cyclin D1 interacts with CDK4 and CDK6, whose activity is required for the cell cycle G1/S transition. Cyclin D1 also interacts with tumor suppressor protein Rb. Mutations in the Bcl-1 gene are associated with a variety of cancers, including esophageal, breast, and bladder cancer, as well as a variety of B-cell-related leukemias and lymphomas.

These products are affinity-purified IgG antibodies that recognize human cyclin D1. The antibodies were raised in mouse using a recombinant protein, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human cyclin D1 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 11011A, 11011B
  • Target Name: Human cyclin D1
  • Antigen: Human cyclin D1 recombinant protein
  • Application: WB, IHC
  • Specificity: Cross-reacts with cyclin D2
  • Target Entrez Gene ID: 595

  • Cat.#: 11012A
  • Target Name: Human cyclin D1
  • Antigen: Human cyclin D1 recombinant protein
  • Note: Biotin-conjugated
  • Application: WB, IHC
  • Specificity: Cross-reacts with cyclin D2
  • Target Entrez Gene ID: 595

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL
  • Immunohistochemical techniques: 2–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

CCND1, B-cell lymphoma 1 protein, BCL1, parathyroid adenomatosis 1, PRAD1, B-cell CLL/lymphoma 1, G1/S-specific cyclin-D1, D11S287E, U21B31




 
 
Products
Cat. # Product Package Size Price # of Units Select
11011A Anti-Bcl-1/cyclin D1 (5D4) Mouse IgG MoAb 1 mL $606.00 *
11011B Anti-Bcl-1/cyclin D1 (5D4) Mouse IgG MoAb 200 ug $499.00
11012A Anti-Bcl-1/cyclin D1 (5D4) Mouse IgG MoAb Biotin 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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