The septin gene family of nucleotide binding proteins were originally identified in yeast as cell division regulatory proteins. Septin 7 is highly similar to yeast CDC10 protein, and is similar to Drosophila Diff 6 and mouse H5. Each of these proteins contains a GTP-binding motif. Septin 7 is also known as cell division cycle 10 (CDC10) homolog (S. cerevisiae), CDC3, CDC10, SEPT7A, and NBLA02942. It functions in gliomagenesis and in the suppression of glioma cell growth. It is required for the association of centromere-associated protein E with the kinetochore during mitosis. Alternative splicing results in multiple isoforms of septin-7. Abnormal expression patterns of some septins have been reported in human cancers and neurodegenerative diseases.
This product is an affinity-purified IgG antibody that recognizes human septin 7 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human septin 7 protein.