The repulsive guidance molecule (RGM) protein family performs several functions in the developing and adult nervous system. The three members--RGMa, RGMb, and RGMc--share a high level of protein sequence identity. RGMa is a glycosylphosphatidylinositol (GIP)-anchored glycoprotein that acts as an axon guidance protein during development of the central nervous system. RGMa regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and regulates the formation of mature synapses. RGMa binds to neogenin as its receptor; overexpression of neogenin and downregulation of RGMa in the developing embryonic neural tube induces apoptosis. RGMa also binds some members of the bone morphogenetic protein (BMP) family. RGMa is also known as RGM domain family, member A; and RGM.
These products are affinity-purified IgG antibodies that recognize human or rat RGMa protein. The antibodies were raised in rabbit or mouse using synthetic peptides and can be used for Western blot (WB) detection, immunoprecipitation (IP), or flow cytometry (FCM) of RGMa protein.