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Products >  Cell_Biology >  Brain_and_CNS >  Antibodies_O-S >  Parkin_Human_Monoclonal

Anti-Human Parkin Mouse IgG MoAb

Parkin is encoded by the PARK2 gene in humans; its precise function is unknown. However, it is known to be part of a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. The ubiquitin-tagged proteins are then degraded by ubiquitin-proteasome complexes. Mutations in the PARK2 gene are associated with familial and autosomal recessive juvenile forms of Parkinson disease. It has been suggested that loss of function of the parkin protein leads to dopaminergic cell death, but the mechanism is not clear. Parkin is also known as Parkinson protein 2, E3 ubiquitin protein ligase; Parkinson disease (autosomal recessive, juvenile) 2, parkin; E3 ubiquitin-protein ligase parkin, Parkinson disease protein 2, PDJ, PRKN, AR-JP, and LPRS2.

These products are affinity-purified IgG antibodies that recognize human parkin protein. The antibodies were raised in mouse using synthetic peptides and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, immunocytochemical (ICC) detection, or immunoprecipitation (IP) of human parkin protein.

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Features

  • Cat. #: 10241A, 10241B
  • Target Name: Human parkin protein
  • Antigen: Human parkin C-terminal synthetic peptide
  • Clone: 1A1
  • Application: WB, ICC, IP
  • Specificity: Cross-reacts with mouse and rat parkin
  • Target Entrez Gene ID: 5071

  • Cat.#: 10243A, 10243B
  • Target Name: Human parkin protein
  • Antigen: Human parkin C-terminal synthetic peptide
  • Clone: 5A1
  • Application: WB, IHC, IP
  • Specificity: Cross-reacts with mouse and rat parkin
  • Target Entrez Gene ID: 5071

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1 µg/mL (Cat.# 10241); 5 µg/mL (Cat.# 10243)
  • Immunohistochemical techniques: 5 µg/mL
  • Immunocytochemical techniques: 5 µg/mL
  • Immunoprecipitation: 3 µg per reaction

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Parkinson protein 2, E3 ubiquitin protein ligase; Parkinson disease (autosomal recessive, juvenile) 2, parkin; E3 ubiquitin-protein ligase parkin, Parkinson disease protein 2, PARK2, PDJ, PRKN, AR-JP, LPRS2




 
 
Products
Cat. # Product Contents Size Price Units Select
10241A Anti-Human Parkin (1A1) Mouse IgG MoAb 10 ug $113.00 *
10241B Anti-Human Parkin (1A1) Mouse IgG MoAb 100 ug $499.00
10243A Anti-Human Parkin (5A1) Mouse IgG MoAb 10 ug $113.00 *
10243B Anti-Human Parkin (5A1) Mouse IgG MoAb 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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