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Products >  Cell_Biology >  Brain_and_CNS >  Antibodies_O-S >  Alpha-Synuclein_Human

Anti-Human alpha-Synuclein (S122) Rabbit IgG Antibody

The synuclein family (alpha, beta, and gamma synuclein) of proteins is expressed at high levels in adult brain, and in some tumors. Alpha-synuclein is encoded by the SNCA gene in humans. It is also known as non A-beta component of AD amyloid, non-A4 component of amyloid precursor, NACP, PD1, PARK1, and PARK4.

The function of alpha-synuclein is unknown, but it may be involved in presynaptic signaling and membrane trafficking. Alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions, such as Parkinson's disease, Lewy body dementia (associated with both Alzheimer's and Parkinson's disease), and multiple system atrophy. Alpha-synuclein peptides are also known to be a significant component of amyloid plaques in the brains of patients with Alzheimer's disease. Mutations in the SNCA gene have been associated with the pathogenesis of Parkinson disease.

This product is an affinity-purified IgG antibody that recognizes human alpha-synuclein protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human alpha-synuclein protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18671A, 18671B
  • Target Name: Human alpha-synuclein protein
  • Antigen: Human alpha-synuclein C-terminal synthetic peptide
  • Application: WB, IHC
  • Specificity: Cross-reacts with mouse and rat alpha-synuclein
  • Target Entrez Gene ID: 6622

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 0.5–2.0 µg/mL
  • Immunohistochemical techniques: 2 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

SNCA, non A-beta component of AD amyloid, non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4




 
 
Products
Cat. # Product Package Size Price # of Units Select
18671A Anti-Human alpha-Synuclein (S122) Rabbit IgG Affinity Purify 10 ug $113.00 *
18671B Anti-Human alpha-Synuclein (S122) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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