The synuclein family (alpha, beta, and gamma synuclein) of proteins is expressed at high levels in adult brain, and in some tumors. Alpha-synuclein is encoded by the SNCA gene in humans. It is also known as non A-beta component of AD amyloid, non-A4 component of amyloid precursor, NACP, PD1, PARK1, and PARK4.
The function of alpha-synuclein is unknown, but it may be involved in presynaptic signaling and membrane trafficking. Alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions, such as Parkinson's disease, Lewy body dementia (associated with both Alzheimer's and Parkinson's disease), and multiple system atrophy. Alpha-synuclein peptides are also known to be a significant component of amyloid plaques in the brains of patients with Alzheimer's disease. Mutations in the SNCA gene have been associated with the pathogenesis of Parkinson disease.
This product is an affinity-purified IgG antibody that recognizes human alpha-synuclein protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human alpha-synuclein protein.