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Products >  Cell_Biology >  Brain_and_CNS >  Antibodies_G-N >  Neurofilament_Monoclonal

Anti-Neurofilament, 160K, 210K, (N21-8-4) Mouse Ascites MoAb

Neurofilaments (NF) are a key component of the neuronal cytoskeleton, and are responsible for providing structural support to the axon and regulating axon diameter. Mammalian neurofilaments are composed of three major subunits, classified based on molecular weight in SDS-PAGE: light (NF-L), 68-70 kDa; medium (NF-M), 145-160 kDa; and heavy (NF-H), 200-220 kDa. In humans, these proteins are encoded by the NEFL, NEFM, and NEFH genes, respectively. NF-M is also known as neurofilament, medium polypeptide; neurofilament, medium polypeptide 160kDa; NEF3, neurofilament 3, neurofilament triplet M protein, and 160 kDa neurofilament protein. NF-H is also known as neurofilament, heavy polypeptide; neurofilament, heavy polypeptide 200kDa; KIAA0845, neurofilament triplet H protein, and 200 kDa neurofilament protein.

This product is an affinity-purified IgG antibody that recognizes human and bovine NF-M and NF-H subunits. The antibody was raised in mouse using bovine brain neurofilament and can be used for immunohistochemical (IHC) detection of human and bovine NF-M and NF-H subunits.

At-A-Glance Documents

Features

  • Cat.#: 10096A
  • Target Name: Bovine NF-M and NF-H subunits
  • Antigen: Bovine brain neurofilament protein
  • Specificity: Reacts with bovine and human NF-M and NF-H proteins
  • Application: IHC
  • Target Entrez Gene ID: 281347, 528842

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Immunohistochemical techniques: 200X dilution

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 0.5 mL H2O.

Alternative names

NF-M: Neurofilament, medium polypeptide; neurofilament, medium polypeptide 160kDa; NEF3, neurofilament 3, neurofilament triplet M protein, 160 kDa neurofilament protein NF-H: neurofilament, heavy polypeptide; neurofilament, heavy polypeptide 200kDa; KIAA0845, neurofilament triplet H protein, 200 kDa neurofilament protein




 
 
Products
Cat. # Product Package Size Price # of Units Select
10096A Anti-Neurofilament, 160K, 210K, (N21-8-4) Mouse Ascites MoAb 0.5 mL $499.00
 

 


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