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Products >  Cell_Biology >  Brain_and_CNS >  Antibodies_G-N >  LRRK2_Human

Anti-Human LRRK2 Rabbit IgG Antibody

Leucine-rich repeat kinase 2 (LRRK2) is a large, multi-domain protein that includes leucine-rich repeats and a GTPase domain. LRRK2 is present largely in the cytoplasm but is also known to associate with the mitochondrial outer membrane. It positively regulates autophagy through a calcium-dependent signaling pathway. Mutations in the LRRK2 gene, corresponding to regions within the kinase and GTPase domains, are commonly associated with late-onset Parkinson's disease. Some members of the 14-3-3 family bind to and influence the cytoplasmic localization of LRRK2, and this interaction has been identified as important to the pathogenesis of Parkinson's disease. LRRK2 is also known as Parkinson disease (autosomal dominant) 8 (PARK8), augmented in rheumatoid arthritis 17 (AURA17), leucine-rich repeat serine/threonine-protein kinase 2, dardarin, RIPK7, ROCO2, DKFZp434H2111, and FLJ45829.

This product is an affinity-purified IgG antibody that recognizes human LRRK2 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection of human LRRK2 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 28019A, 28019B
  • Target Name: Human LRRK2 protein
  • Antigen: Human LRRK2 C-terminal synthetic peptide
  • Application: WB
  • Target Entrez Gene ID: 120892

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–3 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Parkinson disease (autosomal dominant) 8, PARK8, augmented in rheumatoid arthritis 17, AURA17, leucine-rich repeat serine/threonine-protein kinase 2, dardarin, RIPK7, ROCO2, DKFZp434H2111, FLJ45829




 
 
Products
Cat. # Product Package Size Price # of Units Select
28019A Anti-Human LRRK2 Rabbit IgG Affinity Purify 10 ug $113.00 *
28019B Anti-Human LRRK2 Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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