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Products >  Cell_Biology >  Brain_and_CNS >  Antibodies_A-F >  Dock8

Anti-Dock8 Rabbit IgG Antibody

The DOCK-C (also called Zir) subfamily of the dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors function as activators of small GTPases. Dock8 was originally identified based on high sequence similarity to Dock180, the archetypal member of the DOCK family. It is also known as dedicator of cytokinesis protein 8, ZIR8, MRD2, FLJ00026, FLJ00152, FLJ00346, and 1200017A24Rik. Like other DOCK proteins, Dock8 has a DHR1 domain that binds phospholipids, and a DHR2 domain containing the guanine nucleotide exchange activity. The cellular function of Dock8 is largely unknown. Mutations in the DOCK8 gene have been reported in a human lung cancer cell line, and DOCK8 deficiency is associated with a variant of combined immunodeficiency, known as Hyperimmunoglobulin E syndrome (HIES).

This product is an affinity-purified IgG antibody that recognizes human Dock8 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection, immunocytochemical (ICC) detection, or immunoprecipitation (IP) of human Dock8 protein.

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Features

  • Cat.#: 28113A, 28113B
  • Target Name: Human Dock8
  • Antigen: Human Dock8 synthetic peptide
  • Application: WB, ICC, IP
  • Specificity: Cross-reacts with mouse and rat Dock8
  • Target Entrez Gene ID: 81704

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 0.2–2.0 µg/mL
  • Immunocytochemical techniques: 10–20 µg/mL
  • Immunoprecipitation: 0.2–2.0 µg per reaction

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

dedicator of cytokinesis protein 8, ZIR8, MRD2, FLJ00026, FLJ00152, FLJ00346, 1200017A24Rik




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
28113A Anti-Dock8 Rabbit IgG Affinity Purify 10 ug $113.00 *
28113B Anti-Dock8 Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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