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Products >  Cell_Biology >  Brain_and_CNS >  Antibodies_A-F >  Dock7_Human

Anti-Human Dock7 Rabbit IgG Antibody

The DOCK-C (also called Zir) subfamily of the dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors function as activators of small GTPases. Dock7 was originally identified based on high sequence similarity to Dock180, the archetypal member of the DOCK family. It is also known as dedicator of cytokinesis protein 7, ZIR2, and KIAA1771. Like other DOCK proteins, Dock7 has a DHR1 domain that binds phospholipids, and a DHR2 domain containing the guanine nucleotide exchange activity. Dock7 expression has been reported in neurons and in HEK 293 cells. It binds the small GTPases Rac1 and Rac3, but does not bind Cdc42. Dock7 is required for proliferation and differentiation of neurocytes and glial cells. Dock7 has also been reported to interact with the hamartin-tuberin complex, which is disrupted in patients with of tuberous sclerosis.

These products are affinity-purified IgG antibodies that recognize human Dock7. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection (Cat.# 28057, 28079), immunocytochemical (ICC) detection (Cat.# 28057), or immunoprecipitation (IP) (Cat.# 28057) of human Dock7.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 28057A, 28057B
  • Target Name: Human Dock7
  • Antigen: Human Dock7 synthetic peptide
  • Application: WB, ICC, IP
  • Specificity: Cross-reacts with rat Dock7
  • Target Entrez Gene ID: 85440

  • Cat.#: 28079A, 28079B
  • Target Name: Human Dock7
  • Antigen: Human Dock7 (phosphorylated) synthetic peptide
  • Application: WB
  • Specificity: Cross-reacts with rat and mouse Dock7
  • Target Entrez Gene ID: 85440

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 0.2–2.0 µg/mL (Cat.# 28057); 1–5 µg/mL (Cat.# 28079)
  • Immunocytochemical techniques: 0.2–2.0 µg/mL
  • Immunoprecipitation: 1–3 µg per reaction

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 50 µg/mL).

Alternative names

dedicator of cytokinesis protein 7, ZIR2, KIAA1771




 
 
Products
Cat. # Product Package Size Price # of Units Select
28057A Anti-Human Dock7 Rabbit IgG Affinity Purify 5 ug $100.00
28057B Anti-Human Dock7 Rabbit IgG Affinity Purify 50 ug $499.00
28079A Anti-Human Dock7 (Y1118 Phosphorylated) Rabbit IgG Affinity Purify 5 ug $100.00
28079B Anti-Human Dock7 (Y1118 Phosphorylated) Rabbit IgG Affinity Purify 50 ug $499.00
 

 



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