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Products >  Cell_Biology >  Brain_and_CNS >  Antibodies_A-F >  Dock6

Anti-Dock6 Rabbit IgG Antibody

The DOCK-C (also called Zir) subfamily of the dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors function as activators of small GTPases. Dock6 was originally identified based on high sequence similarity to Dock180, the archetypal member of the DOCK family. It is also known as dedicator of cytokinesis protein 6, AOS2, ZIR1, and KIAA1395. Like other DOCK proteins, Dock6 has a DHR1 domain that binds phospholipids, and a DHR2 domain containing the guanine nucleotide exchange activity. The cellular function of Dock6 is largely unknown; however, it is reported to exhibit dual guanine nucleotide exchange specificity towards the small GTPases, Rac1 and Cdc42. Mutations in the DOCK6 gene are associated with Adams-Oliver syndrome 2, a rare congenital disorder characterized by defects of the scalp, cranium, and limbs, and mottling of the skin.

This product is an affinity-purified IgG antibody that recognizes human Dock6 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection, immunocytochemical (ICC) detection, or immunoprecipitation (IP) of human Dock6 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 28111A, 28111B
  • Target Name: Human Dock6
  • Antigen: Human Dock6 synthetic peptide
  • Application: WB, ICC, IP
  • Specificity: Cross-reacts with mouse and rat Dock6
  • Target Entrez Gene ID: 57572

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 0.2–2.0 µg/mL
  • Immunocytochemical techniques: 10–20 µg/mL
  • Immunoprecipitation: 0.2–2.0 µg per reaction

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

dedicator of cytokinesis protein 6, AOS2, ZIR1, KIAA1395




 
 
Products
Cat. # Product Package Size Price # of Units Select
28111A Anti-Dock6 Rabbit IgG Affinity Purify 10 ug $113.00 *
28111B Anti-Dock6 Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 



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