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Products >  Cell_Biology >  Brain_and_CNS >  Antibodies_14-3-3 >  14-3-3_Beta_Human

Anti-Human 14-3-3-Beta Protein Rabbit IgG Antibody

The 14-3-3 family of conserved regulatory proteins is expressed in all eukaryotic cells and are encoded by seven genes in mammals. 14-3-3 proteins bind many types of signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 100 signaling proteins have been reported as 14-3-3 ligands. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. Elevated amounts of 14-3-3 proteins are found in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. 14-3-3 beta protein interacts with RAF1 and CDC25 phosphatases, suggesting a role in linking mitogenic signaling and the cell cycle machinery.

This product is an affinity-purified IgG antibody that recognizes human 14-3-3-beta protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection of human 14-3-3-beta protein.

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Features

  • Cat.#: 18641A, 18641B
  • Target Name: Human 14-3-3-beta protein
  • Antigen: Human 14-3-3-beta N-terminal synthetic peptide
  • Application: WB
  • Specificity: Does not cross-react with other 14-3-3 proteins
  • Target Entrez Gene ID: 7529

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, protein 1054, protein kinase C inhibitor protein 1, HS1, GW128, YWHAA, YWHAB, KCIP-1




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
18641A Anti-Human 14-3-3 beta Protein Rabbit IgG Affinity Purify 10 ug $113.00 *
  18641B Anti-Human 14-3-3 beta Protein Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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