Procollagen Type I C-Peptide (PIP) (Human), Monoclonal

These mAb clones recognize procollagen type I C-peptide. They are suitable for the detection of non-denatured antigen released in tissue culture media and for monitoring of collagen synthesis. Procollagens are precursor molecules of Collagens (types I, II, III, IV and V). Procollagens contain additional peptide sequences, usually called "propeptides", at both the amino-terminal and the carboxy-terminal ends. The function of these propeptides is to facilitate the winding of procollagen molecules into a triple-helical conformation within the endoplasmic reticulum. The propeptides are cleaved off from the collagen triple helix molecule during its secretion, after which the triple helix collagens polymerize into extracellular collagen fibrils.