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Cell Biology

Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  sAPP_Beta_Human

sAPP-beta Antibody

The sAPP-beta Antibody is an affinity-purified rabbit IgG antibody that recognizes wild-type (wt) human soluble APP-beta protein. The sAPP-beta Antibody is raised in rabbit using a synthetic peptide and can be applied to Western blot (WB) or immunoprecipitation (IP) of human sAPP-beta.

The accumulation of insoluble amyloid beta protein plaques in the cerebral cortex in Alzheimer's disease (AD) is only one of the hallmarks of amyloid precursor protein (APP) cleavage.  Cleavage by beta- and gamma-secretase (amyloidogenic pathway) leads to production of amyloid-beta and soluble APP-beta, while cleavage by alpha-secretase (nonamyloidogenic pathway) results in a soluble form of APP or sAPP-alpha. Mutations in the APP gene can give rise to variants of both sAPP-alpha and sAPP-beta, and more than 50 different mutations in the APP gene can cause early-onset Alzheimer disease.

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Cat.# 18957A, 18957B
  • Name: Human sAPP-beta-wt
  • Antigen: Human sAPP-beta-wt C-terminal synthetic peptide
  • Application: WB, IP
  • Specificity: Does not cross-react with sAPP-alpha or full-length APP
  • Entrez Gene ID: 351


Recommended antibody concentration (the optimal concentration should be determined empirically)

  • WB: 2 µg/mL
  • IP: 3 µg/mL


Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.


Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute each 10 ug vial in 100 ul H2O and each 100 ug vial in 1.0 mL H2O (final concentration, 100 µg/mL). 

Alternative names


Offers Cat. # Product Contents Size Price Units Select
  18957B Anti-Human sAPP beta-Wild Type Rabbit IgG Affinity Purify 100 ug $499.00
18957A Anti-Human sAPP beta-Wild Type Rabbit IgG Affinity Purify 10 ug $113.00 *
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