Home Takara Clontech Logo Takara Clontech
login | register | order now | view cart | feedback
Products
Cell Biology


Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  sAPP_Beta_Human

sAPP-beta Antibody

The sAPP-beta Antibody is an affinity-purified rabbit IgG antibody that recognizes wild-type (wt) human soluble APP-beta protein. The sAPP-beta Antibody is raised in rabbit using a synthetic peptide and can be applied to Western blot (WB) or immunoprecipitation (IP) of human sAPP-beta.

The accumulation of insoluble amyloid beta protein plaques in the cerebral cortex in Alzheimer's disease (AD) is only one of the hallmarks of amyloid precursor protein (APP) cleavage.  Cleavage by beta- and gamma-secretase (amyloidogenic pathway) leads to production of amyloid-beta and soluble APP-beta, while cleavage by alpha-secretase (nonamyloidogenic pathway) results in a soluble form of APP or sAPP-alpha. Mutations in the APP gene can give rise to variants of both sAPP-alpha and sAPP-beta, and more than 50 different mutations in the APP gene can cause early-onset Alzheimer disease.

  At-A-Glance   Documents   Images & Data

Features

Cat.# 18957A, 18957B
  • Name: Human sAPP-beta-wt
  • Antigen: Human sAPP-beta-wt C-terminal synthetic peptide
  • Application: WB, IP
  • Specificity: Does not cross-react with sAPP-alpha or full-length APP
  • Entrez Gene ID: 351

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically)

  • WB: 2 µg/mL
  • IP: 3 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute each 10 ug vial in 100 ul H2O and each 100 ug vial in 1.0 mL H2O (final concentration, 100 µg/mL). 

Alternative names

AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTF-gamma




 
 
Products
Cat. # Product Contents Size Price Units Select
18957B Anti-Human sAPP beta-Wild Type Rabbit IgG Affinity Purify 100 ug $499.00
18957A Anti-Human sAPP beta-Wild Type Rabbit IgG Affinity Purify 10 ug $113.00 *
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

Clontech is a Takara Bio Company © 2014 Privacy Policy | Terms & Conditions