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Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  Tau_Human

Human Tau Antibody

The Human Tau Antibody products are affinity-purified IgG antibodies that recognize human tau protein isoforms. The anti-human tau antibodies are raised in mouse or rabbit using synthetic peptides or brain tissue isolates and are applicable for Western blot (WB) or immunohistochemistry (IHC) detection of human tau protein isoforms.

The human microtubule-associated protein tau (MAPT) gene transcript undergoes a complex series of alternative splicing events that result in several differentially expressed mRNA species. The protein isoforms translated from these mRNAs are distinguished by the number of binding domains located at their carboxy termini and can range in length from 352 to 441 amino acids.

Tau proteins promote the assembly and stability of microtubules in neuronal cells, and primarily in the distal portions of axons. Mutations in the MAPT gene are associated with a range of neurodegenerative diseases including Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. Hyperphosphorylation of tau proteins leads to the assembly of tangled filaments that are implicated in the pathogenesis of Alzheimer's disease.

Tau is also known as microtubule-associated protein tau (MAPT), neurofibrillary tangle protein, paired helical filament-tau (PHF-tau), G protein beta1/gamma2 subunit-interacting factor 1, MTBT1, MAPTL, DDPAC, MSTD, FTDP-17, MTBT2, PPND, FLJ31424 and MGC138549.

At-A-Glance Documents Images & Data

Features

Cat.#: 10233A, 10233B

  • Target Name: Human tau protein
  • Antigen: Human tau synthetic peptide (amino junction between exons 1 and 4)
  • Clone: 9A1
  • Specificity: Reacts with human tau 352 and 383
  • Application: WB, IHC
  • Target Entrez Gene ID: 4137

    Cat.#: 10235A, 10235B

  • Target Name: Human tau protein
  • Antigen: Human tau synthetic peptide (E2 junction between exons 1 and 4)
  • Clone: 1A1
  • Specificity: Reacts with human tau 381 and 412
  • Application: WB, IHC
  • Target Entrez Gene ID: 4137
  • Cat.#: 10237A, 10237B

  • Target Name: Human tau protein
  • Antigen: Human tau synthetic peptide (repeat domain between exons 1 and 4)
  • Clone: 2B11
  • Specificity: Reacts with human tau 352, 381, 383, 410, 412, and 441
  • Application: WB, IHC
  • Target Entrez Gene ID: 4137
  • Cat.#: 11092A, 11092B

  • Target Name: Human tau protein
  • Antigen: Human tau paired helical filament (PHF) from brain tissue isolate
  • Clone: C5
  • Specificity: Cross-reacts with mouse and rat tau; does not react with nonphosphorylated human tau
  • Application: WB, IHC
  • Target Entrez Gene ID: 4137
  • Cat.#: 18721A

  • Target Name: Human tau protein
  • Antigen: Human tau N-terminal synthetic peptide
  • Specificity: Reacts with human tau 352, 381, 383, 410, 412, and 441
  • Application: WB, IHC
  • Target Entrez Gene ID: 4137
  • Applications

    Recommended antibody concentration (Note: optimal concentration should be determined empirically):

    • Western blot: 1–5 µg/mL
    • Immunohistochemistry: 1–5 µg/mL

    Storage

    Lyophilized: stable up to 5 years at 2–8°C. In solution: stable up to 2 years at –20°C.

    Form

    Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

    Alternative names

    Microtubule-associated protein tau, MAPT, neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, G protein beta1/gamma2 subunit-interacting factor 1, MTBT1, MAPTL, DDPAC, MSTD, FTDP-17, MTBT2, PPND, FLJ31424, MGC138549




     
     
    Products
    Cat. # Product Package Size Price # of Units Select
    10235B Anti-Human Tau/E2 Junction (1A1) Mouse IgG MoAb 100 ug $499.00
    10237A Anti-Human Tau/Repeat Domain (2B11) Mouse IgG MoAb 10 ug $113.00 *
    10237B Anti-Human Tau/Repeat Domain (2B11) Mouse IgG MoAb 100 ug $499.00
    10233A Anti-Human Tau/Amino Junction (9A1) Mouse IgG MoAb 10 ug $113.00 *
    10233B Anti-Human Tau/Amino Junction (9A1) Mouse IgG MoAb 100 ug $499.00
    10235A Anti-Human Tau/E2 Junction (1A1) Mouse IgG MoAb 10 ug $113.00 *
    11092A Anti-Human Tau (Phosphorylated) (C5) Mouse IgG MoAb 10 ug $113.00 *
    11092B Anti-Human Tau (Phosphorylated) (C5) Mouse IgG MoAb 100 ug $499.00
    18721A Anti-Human Tau Rabbit IgG Affinity Purify 100 ug $499.00
    * You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
     

     


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