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Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  Presenilin-1_Human_Monoclonal

Anti-Human Presenilin-1 (17C2) Mouse IgG MoAb

Presenilin 1, encoded by the PSEN1 gene, is one of several proteins that are thought to regulate processing of amyloid precursor protein (APP) through their effects on gamma-secretase, an enzyme that cleaves APP. Presenilins are also thought to be involved in the cleavage of the Notch receptor, a transmembrane protein that is involved in a complex signaling pathway during neurogenesis. Patients with an inherited form of Alzheimer's disease have mutations in the PSEN1 and PSEN2 genes that result in aberrant presenilin function and increased buildup of amyloid deposits in the brain. Presenilin 1 is also known as Alzheimer disease 3 (AD3), FAD, PS1, PSNL1, and S182.

This product is an affinity-purified IgG antibody that recognizes human presenilin 1 protein. The antibody was raised in mouse using recombinant presenilin 1 and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human presenilin 1 protein.

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Features

  • Cat.#: 10151A
  • Target Name: Human presenilin 1 protein
  • Antigen: Human presenilin 1 (N-terminal fragment) recombinant protein
  • Specificity: Does not cross-react with human presenilin 2
  • Application: WB, IHC
  • Target Entrez Gene ID: 5663

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 5 µg/mL
  • Immunohistochemical techniques: 10 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

PSEN1, Alzheimer disease 3, AD3, FAD, PS1, PSNL1, S182




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
10151A Anti-Human Presenilin-1 (17C2) Mouse IgG MoAb 200 ug $499.00
 

 

 
 

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