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Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  Drebrin_A_DAS2

Anti-Drebrin A (DAS2) Rabbit IgG Antibody

Drebrin (developmentally regulated brain protein) is one of several proteins encoded by the DBN1 gene in humans. It is a cytoplasmic actin-binding protein that plays a role in neuronal growth and cell migration. The drebrin family of proteins are developmentally regulated in the brain. Downregulation of the DBN1 gene is implicated in the pathogenesis of Alzheimer's disease. Two major isoforms are known: drebrin A and drebrin E. Drebrin A was found to cluster at neuronal synapses in adult brain, and drebrin A upregulation was shown to play an important role in spine morphogenesis and activity-dependent synaptic targeting of N-methyl-D-aspartate (NMDA) receptors. These receptors are involved in the cellular mechanism for learning and memory. A decrease in drebrin A expression is associated with memory loss and decline of cognitive function in patients with Alzheimer's disease.

This product is an affinity-purified IgG antibody that recognizes human, mouse, and rat drebrin A protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of drebrin A.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 28023A, 28023B
  • Target Name: Drebrin A protein
  • Antigen: Drebrin A synthetic peptide
  • Application: WB, IHC, IP
  • Specificity: Reacts with human, mouse, and rat drebrin A; does not cross-react with other drebrin isoforms
  • Target Entrez Gene ID: 1627

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 0.325–1.3 µg/mL
  • Immunohistochemical techniques: 0.325–0.65 µg/mL
  • Immunoprecipitation: 0.325–0.65 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration, 50 µg/mL).

Alternative names

DOS117




 
 
Products
Cat. # Product Package Size Price # of Units Select
28023A Anti-Drebrin A (DAS2) Rabbit IgG Affinity Purify 5 ug $113.00 *
28023B Anti-Drebrin A (DAS2) Rabbit IgG Affinity Purify 50 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 



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