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Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  ApoE4_Human_Monoclonal

Anti-Human ApoE4 (5B5) Mouse IgG Antibody

Apolipoprotein E (ApoE) is a main apoprotein of the chylomicron--lipoprotein particles that contain triglycerides, phospholipids, cholesterol, and proteins. It is also known as Apo-E, AD2, LPG, and LDLCQ5. Three isoforms of ApoE are produced by alternative splicing: ApoE2, ApoE3, and ApoE4. The primary role of ApoE is to transport lipoproteins, fat-soluble vitamins, and cholesterol into the lymph and then into the blood. Normal functioning of ApoE is essential to prevent the accumulation of cholesterol and triglycerides in the blood. ApoE expression is highest in the liver, but has also been found in other tissues such as the brain, kidneys, spleen, and nervous system. The ApoE receptor belongs to the highly conserved low density lipoprotein (LDL) receptor gene family; seven mammalian ApoE receptors have been identified. Mutations in the APOE gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III). Recent studies have implicated roles for ApoE in processes that are not directly related to lipid transport, including Alzheimer's disease (AD), immunoregulation, and cognitive function.

This product is an affinity-purified IgG antibody that recognizes human ApoE4 protein. The antibody was raised in mouse using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human ApoE4 protein.

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Features

  • Cat.#: 10025A, 10025B
  • Target Name: Human ApoE4 protein
  • Antigen: Human ApoE4 synthetic peptide
  • Application: WB, IHC
  • Specificity: Does not cross-react with ApoE2 or ApoE3
  • Target Entrez Gene ID: 348

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 10 µg/mL
  • Immunohistochemical techniques: 1–2 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 200 µg/mL).

Alternative names

Apo-E, AD2, LPG, LDLCQ5




 
 
Products
Cat. # Product Contents Size Price Units Select
10025A Anti-Human ApoE4 (5B5) Mouse IgG MoAb 10 ug $113.00 *
10025B Anti-Human ApoE4 (5B5) Mouse IgG MoAb 200 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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