The accumulation of amyloid-beta protein in the cerebral cortex in Alzheimer's disease (AD) is responsible for plaque formation. Amyloid-beta is produced by proteolytic cleavage of amyloid precursor protein (APP), mediated by the enzymes beta- and gamma-secretase. The cleavage reaction produces a number of peptides, ranging from 36 to 43 amino acids in length. These antibodies can detect different amyloid-beta variants that are cleaved at the N-terminus or C-terminus.
These products are affinity-purified IgG antibodies that recognize human amyloid-beta variants. The antibodies were raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of amyloid-beta variants.