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Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  Anti-Human_Amyloid_beta_Rabbit_IgG_Affinity_Purify

Anti-Human Amyloid-beta Rabbit IgG Antibody

The accumulation of amyloid-beta protein in the cerebral cortex in Alzheimer's disease (AD) is responsible for plaque formation. Amyloid-beta is produced by proteolytic cleavage of amyloid precursor protein (APP), mediated by the enzymes beta- and gamma-secretase. The cleavage reaction produces a number of peptides, ranging from 36 to 43 amino acids in length. These antibodies can detect different amyloid-beta variants that are cleaved at the N-terminus or C-terminus.

These products are affinity-purified IgG antibodies that recognize human amyloid-beta variants. The antibodies were raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of amyloid-beta variants.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18584A, 18584B, 18584C
  • Target Name: Human amyloid-beta (N)
  • Antigen: Human amyloid-beta N-terminal synthetic peptide
  • Application: IHC, WB, IP
  • Specificity: Cross-reacts with with human amyloid-beta (1-40), (1-42), and (1-43)
  • Target Entrez Gene ID: 351

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Immunohistochemical techniques: 1–5 µg/mL
  • Western blot: 1–5 µg/mL
  • Immunoprecipitation: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration, 100 µg/mL)

Alternative names:

AAA; A4; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTF-gamma; Alzheimer disease amyloid protein; cerebral vascular amyloid peptide; protease nexin-II; peptidase nexin-II




 
 
Products
Cat. # Product Package Size Price # of Units Select
18584A Anti-Human Amyloid beta (N) Rabbit IgG Affinity Purify 10 ug $113.00 *
18584B Anti-Human Amyloid beta (N) Rabbit IgG Affinity Purify 2 x 5 ug $113.00 *
18584C Anti-Human Amyloid beta (N) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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