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Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  Anti-Human_Amyloid_beta_Mouse_IgG_MoAb

Human Amyloid-beta Antibodies

Human Amyloid beta Antibodies are affinity-purified IgGs that recognize the human amyloid-beta variants indicated below (Cat.# 10326A, 10326B are biotin-conjugated antibodies). Each human amyloid-beta antibody product in this series was raised in mouse using a synthetic peptide. These antibodies can be used for Western blot (WB) and immunohistochemical (IHC) detection; they may also be used for immunoprecipitation (IP) of human amyloid-beta variants.

The accumulation of amyloid-beta protein plaques in the cerebral cortex is believed to be the the fundamental cause of Alzheimer's disease (AD) as well as other dementia-associated diseases. Amyloid-beta is produced by the proteolytic cleavage of amyloid precursor protein (APP), which is mediated by the enzymes beta- and gamma-secretase. The cleavage reaction produces a number of peptides ranging from 36 to 43 amino acids in length. Takara Bio's Human Amyloid-beta Antibodies can detect different amyloid-beta protein variants that are cleaved at either the N- or C-terminus.

At-A-Glance Documents Images & Data

Features

Cat.#: 10027A, 10027B

  • Target Name: Human amyloid-beta (11-28)
  • Antigen: Human amyloid-beta (11-28) synthetic peptide
  • Application: IHCWB, IP
  • Specificity: Cross-reacts with human amyloid-beta (1-40), (1-42) and (1-43)
  • Target Entrez Gene ID: 351

Cat.#: 10323A, 10323B, 10326A, 10326B

  • Target Name: Human amyloid-beta (1-16)
  • Antigen: Human amyloid-beta (1-16) synthetic peptide
  • Application: IHC, WB, IP
  • Specificity: Does not cross-react with mouse or rat amyloid-beta (1-16)
  • Target Entrez Gene ID: 351

Cat.#: 10379A, 10379B

  • Target Name: Human E22P-amyloid-beta (10-35)
  • Antigen: Human E22P-amyloid-beta (10-35) synthetic peptide
  • Application: IHC, WB, IP
  • Specificity: Cross-reacts with native human amyloid-beta (1-40), (1-42)
  • Target Entrez Gene ID: 351

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Immunohistochemical techniques: 1-5 µg/mL
  • Western blot: 1–5 µg/mL
  • Immunoprecipitation: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute each 5 ug vial in 50 ul H2O and each 50 ug vial in 0.5 mL H2O (final concentration, 100 µg/mL).

Alternative names

AAA; A4; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTF-gamma; Alzheimer disease amyloid protein; cerebral vascular amyloid peptide; protease nexin-II; peptidase nexin-II




 
 
Products
Cat. # Product Package Size Price # of Units Select
10027A Anti-Human Amyloid beta (11-28) (12B2) Mouse IgG MoAb 5 ug $113.00 *
10027B Anti-Human Amyloid beta (11-28) (12B2) Mouse IgG MoAb 50 ug $499.00
10323A Anti-Human Amyloid beta (N) (82E1) Mouse IgG MoAb 5 ug $113.00 *
10323B Anti-Human Amyloid beta (N) (82E1) Mouse IgG MoAb 50 ug $499.00
10326A Anti-Human Amyloid beta (N) (82E1) Mouse IgG MoAb Biotin 5 ug $113.00 *
10326B Anti-Human Amyloid beta (N) (82E1) Mouse IgG MoAb Biotin 50 ug $499.00
10379A Anti-Human Amyloid beta E22P (11A1) Mouse IgG MoAb 5 ug $113.00 *
10379B Anti-Human Amyloid beta E22P (11A1) Mouse IgG MoAb 50 ug $499.00
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