Home Takara Clontech Logo Takara Clontech
login | register | order now | view cart | feedback
Products
Cell Biology


Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  APP770

Human APP770 Antibody

Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta protein in the cerebral cortex, derived from proteolytic cleavage of amyloid precursor protein (APP). More than 50 different mutations in the APP gene can cause early-onset Alzheimer disease. Several different types of APP are produced by alternative splicing of transcripts from the APP gene; the most abundant isoforms are APP695, APP751, and APPP770. APP770 has been detected primarily in cerebrovascular endothelial cells, but its expression has also been reported in other tissues. Amyloid-beta derived from APP770 can accumulate on cerebrovascular walls. Release of APP770 from inflamed endothelial cells and activated platelets has been suggested as a biomarker for acute coronary syndrome. APP is also known as amyloid beta (A4) precursor protein; AD1, cerebral vascular amyloid peptide (CVAP), protease nexin-II (PN-II), pre-A4, ABPP, APPI, AAA, ABETA, and CTFgamma.

This product is an affinity-purified IgG antibody that recognizes human APP770 protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human APP770 protein.

  At-A-Glance   Documents

Features

  • Cat.#: 28133A, 28133B
  • Target Name: Human APP770 protein
  • Antigen: Human APP770 synthetic peptide
  • Application: WB, IHC
  • Target Entrez Gene ID: 351

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2 µg/mL
  • Immunohistochemical techniques: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Amyloid beta (A4) precursor protein; AD1, cerebral vascular amyloid peptide, CVAP, protease nexin-II, PN-II, pre-A4, ABPP, APPI, AAA, ABETA, CTFgamma.




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
28133A Anti-Human APP770 (351) Rabbit IgG Affinity Purify 10 ug $114.00 *
28133B Anti-Human APP770 (351) Rabbit IgG Affinity Purify 100 ug $525.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

Clontech is a Takara Bio Company © 2014 Privacy Policy | Terms & Conditions