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Products >  Cell_Biology >  Alzheimers_Disease >  Antibodies >  APP

Alzheimer's Disease: Anti-APP Antibody

The Anti-APP Antibody products are intended for Alzheimer's disease research and consist of affinity-purified IgG antibodies that recognize variants of the amyloid precursor protein (APP). These APP antibodies are raised in rabbit or mouse using synthetic peptides and can be applied to Western blot (WB) detection or immunoprecipitation (IP) of the indicated APP protein variants.

The accumulation of amyloid-beta protein plaques in the cerebral cortex of Alzheimer's disease (AD) patients is proposed to result from an excess of the amyloid precursor protein (APP) as well as its aberrant cleavage, leading to the Alzheimer disease etiology. Over 50 different mutations in the APP gene have been linked with early-onset Alzheimer disease. The APP is cleaved by beta- and gamma-secretase via the amyloidogenic pathway, which leads to production of amyloid-beta and soluble APP-beta (sAPP-beta); cleavage by alpha-secretase  via the nonamyloidogenic pathway results in sAPP-alpha. Several mutations in the APP gene can give rise to variants of both sAPP-alpha and sAPP-beta.

At-A-Glance Documents Images & Data

Features

Cat.#: 11090A, 11090B
  • Target Name: Human APP
  • Antigen: Human APP N-terminal synthetic peptide
  • Clone: 10D1
  • Application: WB, IP
  • Specificity: Does not cross-react with mouse APP. Reacts with all isoforms of APP695, APP751 and APP770, and soluble APP (sAPP-alpha and -beta)
  • Target Entrez Gene ID: 351
Cat.#: 18961A, 18961B
  • Target Name: Human APP
  • Antigen: Human APP C-terminal synthetic peptide
  • Application: WB, IP
  • Specificity: Cross-reacts with mouse and rat APP. Reacts with all isoforms of APP695, APP751 and APP770. Does not react with soluble APP (sAPP-alpha or -beta).
  • Target Entrez Gene ID: 351
Cat.#: 28021A, 28021B
  • Target Name: Human APP (phosphorylated)
  • Antigen: Human APP (phosphorylated) synthetic peptide
  • Application: WB, IP
  • Specificity: Cross-reacts with mouse phosphorylated APP. Does not cross-react with nonphosphorylated APP
  • Target Entrez Gene ID: 351
Cat.#: 28053A, 28053B
  • Target Name: Human APP
  • Antigen: Human APP (18) synthetic peptide
  • Application: WB
  • Specificity: Cross-reacts with mouse and rat APP. Cross-reacts with sAPP-alpha and sAPP-beta.
  • Target Entrez Gene ID: 351
Cat.#: 28055A, 28055B
  • Target Name: Mouse/rat sAPP-alpha
  • Antigen: Mouse/rat APP (597) C-terminal synthetic peptide
  • Application: WB, IP
  • Specificity: Does not cross-react with human sAPP-alpha, or human/mouse/rat sAPP-beta
  • Target Entrez Gene ID: 351

Applications

Recommended antibody concentration (Note: Optimal concentration should be determined empirically)

  • Western blot: 1–5 µg/mL
  • Immunoprecipitation: 3 µg/mL

Storage

Lyophilized: stable up to 5 years at 2–8°C. In solution: stable up to 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTF-gamma




 
 
Products
Cat. # Product Package Size Price # of Units Select
11090A Anti-Human APP (N) (10D1) Mouse IgG MoAb 10 ug $100.00
11090B Anti-Human APP (N) (10D1) Mouse IgG MoAb 100 ug $499.00
18961A Anti-Human APP (C) Rabbit IgG Affinity Purify 10 ug $100.00
18961B Anti-Human APP (C) Rabbit IgG Affinity Purify 100 ug $499.00
28053A Anti-APP (18) Rabbit IgG Affinity Purify 10 ug $100.00
28053B Anti-APP (18) Rabbit IgG Affinity Purify 100 ug $499.00
28055A Anti-Mouse/Rat APP (597) Rabbit IgG Affinity Purify 10 ug $100.00
28021A Anti-APP (Phosphorylated) Rabbit IgG Affinity Purify 10 ug $100.00
28021B Anti-APP (Phosphorylated) Rabbit IgG Affinity Purify 100 ug $499.00
28055B Anti-Mouse/Rat APP (597) Rabbit IgG Affinity Purify 100 ug $499.00
 

 



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