The Human IgG EIA Kit is a colorimetric sandwich ELISA for quantitative determination of human IgG in human blood and body fluid samples. IgG is produced by plasma cells differentiated from activated B lymphocytes and functions as many roles; as various types of immune antibodies, as neutralizing antibodies that destroy infectiveness, and as opsonizing antibodies that help capture bacteria.
IgG is a placenta-patency plasma protein produced by lymph nodes, spleen, bone marrow, thymus, small intestinal mucosa, and respiratory tract mucosa, among other tissues. Since IgG is produced as the body's response to stimulations by bacteria, viruses, drugs, and tissue antigens, measuring the blood level of IgG can reveal any hyperresponse to antigen stimulations or anomalies at IgG-producing sites, among other disorders. The presence of high IgG levels has been linked to polyclonal hypergammaglobulinemia, collagen disease, asymptomatic M-proteinemia, chronic infections, myeloma, and IgG multiple myeloma, and other pathological conditions and diseases. A low IgG level, on the other hand, has been known to associate with disorders such as agammaglobulinemia or hypogammaglobulinemia, severe immunodeficiency, and nephrosis syndrome.
