The Rat IgE EIA Kit is designed to assay rat IgE using two different monoclonal antibodies that are rat IgE-specific and do not cross-react with other rat immunoglobulins. This highly sensitive immunoassay allows accurate determination of the total amount of IgE in rat serum or other samples with excellent reproducibility.
Immunoglobulins (Ig) are a type of serum globulin proteins, and are known to be involved in the immune process. There are five classes of immunoglobulins (IgG, IgA, IgM, IgD, and IgE), among which IgE is responsible for allergic responses. Serum IgE may be assayed to identify responses to a panel of allergy-causing substances (allergens). Furthermore, the total amount of IgE in blood is one of the criteria to determine type I allergy diseases and atopic diseases. Use of the rat as an experimental model in studies of allergic diseases has the advantage of providing a larger amount of serum sample than mouse, and it enables collection of time-dependent serum samples.
