License Statements

5' Nuclease research kit

Use of this product is covered by one or more of the following US patents and corresponding
patent claims outside the US: 5,079,352, 5,789,224, 5,618,711, 6,127,155, 5,677,152, 5,773,258,
5,407,800,5,322,770,5,310,652,5,487,972, 5,210,015, 5,804,375, 5,538,848, 5,723,591, 5,876,930, 6,030,787, 6,258,569, 6,214,979 and claims outside the US corresponding
to US Patent No. 4,889,818. The purchase of this product includes a limited, non-transferable
immunity from suit under the foregoing patent claims for using only this amount of product for
the purchaser's own internal research. No right under any other patent claim (such as apparatus
or system claims in US Patent No. 6,814,934) and no right to perform commercial services of
any kind, including without limitation reporting the results of purchaser's activities for a fee or
other commercial consideration is conveyed expressly, by implication, or by estoppel. This
product is for research use only. Diagnostic uses under Roche patents require a separate license
from Roche. Further information on purchasing licenses may be obtained by contacting the
Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California
94404, USA.

6xHN Tag

This product is covered by U.S. Patent No. 7,176,298.

ABPD-based Products

The ABPD backbone is by U.S. Patent No. 5,451,463.

Adenoviral Expression Products

This product is covered by the U.S. Patent No. 6,303,362.

Advantage® and TITANIUM™ PCR Products

U.S. Patent No. 5,436,149 for LA Technology is owned by Takara Bio Inc.

Antibody Array Products

Use of the Antibody Array in combination with its associated buffers is covered by U.S Patent No. 7,354,721.

Aureobasidin Drug

This product is covered by the claims of U.S. Patent No. 5,057,493 and its foreign counterpart patent claims owned by Takara Bio Inc.  Rights to use this product are limited to research only.  Use of this product for purposes other than research may require a license, and inquiry concerning such commercial use should be directed to Takara Bio Inc., Seta 3-4-1, Otsu, Shiga 520-2193, Japan.

Aureobasidin Resistance Gene

This product is covered by the claims of U.S. Patent No. 6,015,689 and its foreign counterpart patent claims owned by Takara Bio Inc.  Rights to use this product are limited to research only.  Use of this product for purposes other than research may require a license, and inquiry concerning such commercial use should be directed to Takara Bio Inc., Seta 3-4-1, Otsu, Shiga 520-2193, Japan.

Benzonase® Nuclease

Benzonase Nuclease is manufactured by Merck KGaA, Darmstadt, Germany and is covered by US Patent No. 5,173,418 and EP Patent No. 0229866. Nycomed Pharma A/S (Denmark) claims worldwide patent rights to Benzonase Nuclease, which is licensed exclusively to Merck KGaA, Darmstadt, Germany. Benzonase is a registered trademark of Merck KGaA, Darmstadt, Germany.

cPPT Element

This product and its use are the subject of U.S. Pat. No. 6,682,907 and pending foreign patent applications licensed to Clontech. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and com­ponents of the product in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The buyer cannot disclose information, sell or otherwise transfer this product, its components or materials made using this product or its components to a third party or otherwise use this product or its components or materials made using this product or its components for any com­mercial purposes. If the buyer is not willing to accept the limitations of this limited use statement, Clontech is willing to accept return of the product with a full refund. For information on purchasing a license to the DNA-Flap technology for purposes other than research, contact the Transfer of Technology Office, Institut Pasteur, 28 rue du Docteur Roux, 75 724 Paris Cedex 15 (www.pasteur.fr).

ds DNA Binding Dye Research Kit

Use of this product is covered by one or more of the following US patents and corresponding
patent claims outside the US: 5,079,352, 5,789,224, 5,618,711, 6,127,155, 5,677,152, 5,773,258,
5,407,800,5,322,770,5,310,652,5,994,056,6,171,785, and claims outside the US corresponding
to US Patent No. 4,889,818. The purchase of this product includes a limited, non-transferable
immunity from suit under the foregoing patent claims for using only this amount of product for
the purchaser's own internal research. No right under any other patent claim (such as apparatus
or system claims in US Patent No. 6,814,934) and no right to perform commercial services of
any kind, including without limitation reporting the results of purchaser's activities for a fee or
other commercial consideration is conveyed expressly, by implication, or by estoppel. This
product is for research use only. Diagnostic uses under Roche patents require a separate license
from Roche. Further information on purchasing licenses may be obtained by contacting the
Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California
94404, USA.

DsRed-Monomer and Fruit Fluorescent Proteins

The DsRed Monomer and the Fruit Fluorescent Proteins are covered by one or more of the following U.S. Patents: 7,157,566; 7,393,923; 7,005,511 and 7,250,298.

GC-Melt

GC-Melt is licensed under U.S. Patent No. 5,545,539 and corresponding patents in other countries.

Hot Start Antibody

TaqStart® Antibody and other Hot Start Antibodies are licensed under U.S. Patent No. 5,338,671.

In-Fusion™ Cloning Products

This product is covered by U.S. Patent No 7,575,860 and European Patent No.  EP1741787

Lentiviral Expression Products

Living Colors® Fluorescent Protein Products

Not-For-Profit Entities: Orders may be placed in the normal manner by contacting your local representative or Clontech Customer Service at 650.919.7300. At its discretion, Clontech grants Not-For-Profit Entities a non-exclusive, personal, limited license to use this product for non-commercial life science research use only. Such license specifically excludes the right to sell or otherwise transfer this product, its components or derivatives thereof to third parties. No modifications to the protein coding sequence may be made without express written permission from Clontech. Any other use of this product requires a license from Clontech. For license information, please contact a licensing representative by phone at 650.919.7320 or by e-mail at licensing@clontech.com.  For-Profit Entities wishing to use this product are required to obtain a license from Clontech. For license information, please contact a licensing representative by phone at 650.919.7320 or by e-mail at licensing@clontech.com or click here for more information.

Matchmaker™ Two-Hybrid System

Practice of the two-hybrid system is covered by U.S. Patents No. 5,283,173, No. 5,468,614, and No. 5,667,973 assigned to the Research Foundation of the State University of New York. Purchase of any Clontech two-hybrid reagent does not imply or convey a license to practice the two-hybrid system covered by these patents. Commercial entities purchasing these reagents must obtain a license from the Research Foundation of the State University of New York before using them. Clontech is required by its licensing agreement to submit a report of all purchasers of two-hybrid reagents to SUNY Stony Brook. Please contact SUNY Stony Brook for license information (Tel: 631-632-9009; Fax: 631-632-1505).

Metridia Luciferase

Markova, S.V.,  Golz, S., Frank, L.A., Kalthof, B. & Vysotski, E.S. (2004) Cloning and expression of cDNA for a luciferase from the marine copepod Metridia longa. A novel secreted bioluminescent reporter enzyme. J. Biol. Chem. 279(5):3212–3117.
This product is covered by  U.S. Patent No. 7,297,483.

Molecular Probes, Inc.

This product is provided under an agreement between Molecular Probes, Inc. and Clontech Laboratories, Inc. and the manufacture, use, sale or import of this product is subject to one or more of U.S. Patent Nos. 5,436,134 and 5,658,751, and corresponding international equivalents, owned by Invitrogen Corp. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product in research conducted by the buyer, where such research does not include testing, analysis or screening services for any third party in return for compensation on a per test basis. The buyer cannot sell or otherwise transfer (a) this product (b) its components or (c) materials made using this product or its components to a third party or otherwise use this product or its components or materials made using this product or its components for Commercial Purposes. Commercial Purposes means any activity by a party for consideration and may include, but is not limited to: (1) use of the product or its components in manufacturing; (2) use of the product or its components to provide a service, information, or data; (3) use of the product or its components for therapeutic, diagnostic or prophylactic purposes; or (4) resale of the product or its components, whether or not such product or its components are resold for use in research. For information on purchasing a license to this product for purposes other than research, contact Molecular Probes, Inc., Business Development, 29851 Willow Creek Road, Eugene, OR 97402. Tel: (541) 465-8300, Fax: (541) 335-0354.

MSCV Retroviral Expression Systems

Use of the MSCV Retroviral Expression System is exclusively licensed from Robert G. Hawley, Ph.D. Academic research institutions are granted an automatic license with the purchase of this product to use the MSCV Retroviral Expression System only for internal, academic research purposes. This limitation expressly excludes the right to sell or otherwise transfer the MSCV system or its component parts to third parties. All other users and purchasers are required to obtain a license from Clontech prior to purchasing these reagents or using them for any purpose. For information on licensing please contact a licensing representative by phone at 650.919.7320 or by e-mail at licensing@clontech.com.

One-Step RT PCR

Use of Clontech's One-Step RT-PCR kits is licensed from bioMerieux, is covered by U.S. Patent No. 5,817,465 and equivalents, and is for research use only.

PCR

PCR: NOTICE TO PURCHASER: LIMITED LICENSE Use of this product is covered by one or more of the following US patents and corresponding patent claims outside the US: 5,079,352 and 6,127,155. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser's own internal research. No right under any other patent claim (such as method claims in U.S. Patents Nos. 5,210,015, 5,487,972, 5,994,056 and 6,171,785) and no right to perform commercial services of any kind, including without limitation reporting the results of purchaser's activities for a fee or other commercial consideration, is hereby conveyed by the purchase of this product expressly, by implication, or by estoppel. This product is for research use only. Diagnostic uses require a separate license from Roche. Further information on purchasing licenses may be obtained by contacting the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.

PCR-Select™ cDNA Subtraction

Clontech PCR-Select cDNA Subtraction products are covered by U.S. Patent Nos. 5,565,340 and 5,759,822, as well as pending foreign patent applications. For-Profit and Not-For-Profit purchasers of PCR-Select products are entitled to use the reagents for internal research, including identification of molecular markers or differentially expressed genes; however, the following uses are expressly prohibited:(1) performing services for third parties;(2) identifying nucleic acid sequences to be included on nucleic acid arrays, blots, or in libraries or other cDNA collections which are then sold to third parties; or (3) constructing databases which are then sold to third parties. Reproduction, amplification, modification, reformulation, or resale of the reagents provided in PCR-Select products is not permitted.For information on licensing PCR Select for commercial purposes, please contact a licensing representative by phone at 650.919.7320 or by e-mail at licensing@clontech.com.

pGFP and pGFPuv

Use of CLONTECH's products containing DNA sequences coding for mutant Aequorea victoria green fluorescent protein (GFP) variants or proteins thereof for commercial purposes (e.g., use in manufacturing processes or in the development, screening or discovery of products for therapeutic, diagnostic or prophylactic purposes) requires a license from Columbia University under U.S. Patent Nos. 5,491,084 and/or 6,146,826. All companies and institutions purchasing such products will be included in a quarterly report to Columbia University.

pGFPuv

The cycle 3 mutant GFP gene was produced by Maxygen, Inc. using DNA shuffling technology and is covered by U.S. Patent Nos. 5,605,793 and 5,811,238.

ProLabel™ Detection Products

This product is intended to be used for research purposes only. It is not to be used for drug or diagnostic purposes nor is it intended for human use.

ProteoTuner™ Protein Stabilization/Destabilization Products

Patent Pending.

Reef Coral Fluorescent Proteins, DsRed-Express, and DsRed-Express2

The RCFP's (including DsRedExpress and DsRedExpress2) are covered by one or more of the following U.S.Patents: 7,338,784 ; 7,338,783 ; 7,442,522 ; 7157,565 ; 7,217,789 ; 7,537,915 and 7,166,444

RetroPack™ PT67 Cell Line

The RetroPack PT67 Cell Line is covered under U.S. Patent No. 5,766,945, which has been assigned to the Fred Hutchinson Cancer Research Center. Rights to use this product are limited to research only. No other rights are conveyed. Inquiry into the availability of a license to broader rights or the use of this product for commercial purposes should be directed to Fred Hutchinson Cancer Research Center, Technology Transfer Office, 1100 Fairview Avenue North,C2M-027, Seattle, WA 98109. Purchase of this product does not grant rights to: 1. offer the materials or any derivatives thereof for resale; or  2. to distribute or transfer the materials or any derivatives thereof to third parties.

Retro-Q Vectors

For Research Use Only. Not for Use in Humans.

Retroviral Expression Systems

This product is licensed from Pangenix and its use is covered under U.S. Patent Nos. 5,512,421 and 5,670,354. Rights to use this product are limited to nonhuman research only and use of the patented technology in domestic ungulates is expressly prohibited. No other rights are conveyed. Inquiry into the availability of a license for commercial purposes should be directed to Jane C. Burns, M.D., Pangenix, 6505 El Camino del Teatro, La Jolla, CA 92037.

Retroviral Packaging Systems

Use of this product is  covered by U.S. Patent No. 5,858,740 and is limited to use solely for research purposes. Please contact GBPIP,LLC for a license to use these products for commercial purposes.

Retroviral Vectors

These products are sold under license from the Fred Hutchinson Cancer Research Center. Rights to use this product are limited to research only. No other rights are conveyed. Inquiry into the availability of a license to broader rights or the use of this product for commercial purposes should be directed to Fred Hutchinson Cancer Research Center, Technology Transfer Office, 1100 Fairview Avenue North, J6-200, Seattle, WA 98109. Purchase of this product does not grant rights to:1. offer the materials or any derivatives thereof for resale; or 2. to distribute or transfer the materials or any derivatives thereof to third parties.

Reverse Two-Hybrid Technology

This product is sold under license from Invitrogen IP Holdings, Inc, Carlsbad, CA, for use only in research conducted by the buyer of the product. The buyer is not authorized to use this product or its components for any therapeutic, diagnostic or prophylactic purposes and is not authorized to use this product or its components for any commercial purpose. The buyer is not authorized to sell this product or its components, is not authorized to sell any products made using this product or its components, and is not authorized to perform a service with this product or its components.

RNAi Products

This product is covered by US patent No. 6,506,559.

SfiI Cloning Strategy

Use of the SfiI cloning strategy is licensed under U.S. Patent No. 5,595,895.

SMART™ Amplification Products

SMART Amplification Products are covered by U.S. Patent Nos. 5,962,271 and 5,962,272. For-Profit and Not-For-Profit purchasers of SMART Amplification Products are entitled to use the reagents for internal research. However, the following uses are expressly prohibited:(1) performing services for third parties;(2) identifying nucleic acid sequences to be included on nucleic acid arrays, blots, or in libraries or other cDNA collections which are then sold to third parties. Reproduction, modification, reformulation, or resale of the reagents provided in SMART Amplification Products is not permitted.For information on licensing SMART Technology for commercial purposes, please contact a licensing representative by phone at 650.919.7320 or by e-mail at licensing@clontech.com.

T7 Expression System Products

Academic and Non-Profit Laboratory Assurance Letter: The T7 expression system is based on technology developed at Brookhaven National Laboratory under contract with the U.S. Department of Energy and is the subject of patent applications assigned to Brookhaven Science Associates, LLC. (BSA). BSA will grant a non-exclusive license for use of this technology, including the enclosed materials, based upon the following assurances: 1. These materials are to be used for non-commercial research purposes only. A separate license is required for any commercial use, including the use of these materials for research purposes or production purposes by any commercial entity. Information about commercial licenses may be obtained from the Offi ce of Intellectual Property & Industrial Partnerships, Brookhaven National Laboratory, Bldg. 475D, P.O. Box 5000, Upton, New York 11973-5000, telephone (631) 344-7134. 2. No materials that contain the cloned copy of T7 gene 1, the gene for T7 RNA polymerase, may be distributed further to third parties outside of your laboratory, unless the recipient receives a copy of this license and agrees to be bound by its terms. This limitation applies to strains BL21(DE3), BL21(DE3) pLysS, and BL21(DE3) pLysE, and any derivatives you may make of them. You may refuse this license by returning the enclosed materials unused. By keeping or using the enclosed materials, you agree to be bound by the terms of this license.

TALON® Purification Products

The use of TALON Purification products is covered under U.S. Patent No. 5,962,641.For-Profit and Not-For-Profit purchasers of TALON Purification products are entitled to use the reagents for internal research. For information on licensing TALON Chemistry for commercial purposes, please contact a licensing representative by phone at 650.919.7320 or by e-mail at licensing@clontech.com.

Tet-Based Expression Products

Use of the Tetracycline controllable expression systems (the "Tet Technology") is covered by a series of patents including U.S. Patent Nos. 5,464,758 and 5,814,618, which are proprietary to TET Systems GmbH & Co. KG. Academic research institutions are granted an automatic license with the purchase of this product to use the Tet Technology only for internal, academic research purposes, which license specifically excludes the right to sell, or otherwise transfer, the Tet Technology or its component parts to third parties. Notwithstanding the above, academic and not-for profit research institutions whose research using the Tet Technology is sponsored by for profit organizations, which shall receive ownership to all data and results stemming from the sponsored research, shall need a commercial license agreement from TET Systems in order to use the Tet Technology. In accepting this license, all users acknowledge that the Tet Technology is experimental in nature. TET Systems GmbH & Co. KG makes no warranties, express or implied or of any kind, and hereby disclaims any warranties, representations, or guarantees of any kind as to the Tet Technology, patents, or products. All others are invited to request a license from TET Systems GmbH & Co. KG prior to purchasing these reagents or using them for any purpose. Clontech is required by its licensing agreement to submit a report of all purchasers of the Tet-controllable expression system to TET Systems. For license information, please contact: GSF/CEO,TET Systems GmbH & Co. KG,Im Neuenheimer Feld 582,69120 Heidelberg,Germany Tel: +4962215880400 , Fax: +4962215880404 eMail: info@tetsystems.com or use the electronic licensing request form via http://www.tetsystems.com/main_inquiry.htm

Tranfection Polymers

Use of this product is covered by one or more of the following U.S Patent Nos and corresponding patent claims outside the US: 6,998,115 ; 7,427,394. 

This product is intended for research purposes only.  It may not be used for (i) any human or veterinary use, including without limitation therapeutic and prophylactic use, (ii) any clinical use, including without limitation diagnostic use, (iii) screening of chemical and/or biological compounds for the identification of pharmaceutically active agents (including but not limited to screening of small molecules), target validation, preclinical testing services, or drug development.  Any use of this product for any of the abovementioned purposes requires a license from the Massachusetts Institute of Technology.