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Tricking Toxins: a Fishing Tale

(runtime: 1:46 min)

The marine puffer fish can blow up like a holiday ornament. It also packs a punch: tetrodotoxin (TTX), a deadly alkaloid. How does the fish leverage the poison without succumbing to it? Researchers analyzed puffer fish genes up-regulated by TTX using suppression subtractive hybridization and verified results by RT-PCR. Most genes encoded acute phase proteins, suggesting that a stress response protects against cellular damage. That's Good Science!

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