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Thats_Good_Science >  Watch_the_Videos >  Osteoclast_Development

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Boning Up on miRNA-Regulated
Osteoclast Development

(runtime: 2:07 min)

Bone tissue is a matter of balance: osteoblasts add fresh layers of bone and osteoclasts remove bone tissue. These cells normally work in harmony, but diseases such as osteoporosis or osteopetrosis represent an upset in this balance. Sugatani and colleagues identified upregulation of miR-21 during osteoclastogenesis. They used the Lenti-X system to show that osteoclasts don't form when miR-21 levels are low, suggesting new strategies to promote healthy bones. That's Good Science!

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