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7

Getting the Skinny on Fat with an Inducible Mouse Model

(runtime: 2:18 min)

To understand the physiology of adipocytes, constitutive loss-of-function models can offer a tantalizing glimpse but are an imprecise tool for differentiating short- and long-term effects. Enter the FAT-ATTAC mouse model developed by researchers in Philipp Scherer's lab. They created a clever construct: caspase-8 catalytic domains under the control of an adipocyte-specific promoter that assemble in response to B/B Homodimerizer. Thus, fat cells can be obliterated at will. That's Good Science!

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