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Stem Cell Research


Products >  Stem_Cell_Research >  Antibodies >  Human_Stem_Cell_Antibodies

Human Stem Cell Markers

Induced pluripotent stem (iPS) cells are typically derived by introduction of specific pluripotency-associated factors into somatic cells. For example, ectopic expression of Oct4, Sox2, Lin28, and Nanog in human somatic cells is sufficient to induce pluripotency (Yu et al., 2007). Nanog, Sox2, and Oct4 are transcription factors that are expressed in embryonic stem (ES) cells and are essential for maintaining pluripotency. Lin28 is a microRNA-binding protein that is highly expressed in human ES cells and is thought to regulate self-renewal.

Monoclonal Antibodies to Detect Human Stem Cell Markers
This series of monoclonal antibodies recognize the human stem cell markers Oct4, Lin28, and Sox2. These antibodies can be used to characterize expression of these factors by Western blot or immunocytochemistry.

  At-A-Glance   Documents   Images & Data

Features

 
TargetCat. #CloneAntigen
Human Oct4M221OCT413-12FRecombinant human Oct4 protein (NP_002692)
Human Lin28M222LIN28 91-12ARecombinant full-length human Lin28 protein (NP_078950)
Human Sox2M223SOX 2 9B-12HKLH-conjugated human Sox2 peptide sequence (219-236)

Applications

  • Western blot analysis under reducing conditions
  • Immunocytochemistry

References

Yu, J. et al. (2007) Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science 318:1917–1920.

Additional Information

Please refer to technical documents under the Documents tab for storage conditions, product components, and technical specifications.


 
 
Products
Cat. # Product Contents Size Price Units Select
M221 Oct4 (Human), Monoclonal 0.1 mg $306.00
M222 Lin28 (Human), Monoclonal 0.1 mg $306.00
M223 Sox2 (Human), Monoclonal 0.1 mg $306.00
 

 

 
 

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