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Protein Expression & Purification

Products >  Protein_Expression_and_Purification >  Reagents >  Protease_Inhibitors >  Calpastatin

Calpain Inhibitor: Calpastatin Protease Inhibitor

Calpastatin is an endogenous protease inhibitor that acts specifically on calpain (a calcium-dependent cysteine protease). It contains four repetitive calpain inhibition sequences spanning 120 to 140 amino acid residues (domains I, II, and IV) and an N-terminal non-homologous sequence (domain L). The product consists of highly purified recombinant human calpastatin domain I.

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  • Calpain protease inhibition


Recombinant Human Calpastatin Domain I


Homogeneous on SDS-polyacrylamide gel electrophoresis. Greater than 90% pure as determined by amino acid composition analysis.




Molecular weight:14 kDa
Peptide length:137 a.a.

Typical Activity: 50 nM of calpastatin domain I completely inhibits the activity of 7.5 µg/mL calpain I. 15 nM of calpastatin domain I inhibits 50% of the activity of 7.5 µg/mL calpain I.


Lyophilized white powder


  1. Uemori, T. et al. (1990) Biochem. Biophys. Res. Comm. 166:1485.
  2. Asada, K. et al. (1989) J. Enz. Inhib. 3:49.
  3. Kanaki, R. and Murachi, T. (1987) Protein, Nucleic Acid and Enzyme 32:116 (Japanese Journal).

Cat. # Product Contents Size Price Units Select
7316 Calpastatin 3 mg $235.00



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