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Products >  Inducible_Systems >  Tetracycline-Inducible_Expression >  Tet-tTS

Tet-tTS Transcriptional Silencer

pTet-tTS expresses the tetracycline/doxycycline-controlled transcription silencer (tTS), which is a fusion of the Tet Repressor Protein (TetR) with a KRAB silencing domain. tTS can be used to significantly lower the basal expression from 1st generation Tet-On Inducible Expression Systems. In the absence of doxycycline, tTS binds to the tet-operator sequences within TRE promoters, silencing gene expression. Upon addition of doxycycline, tTS undergoes a conformational changes that causes its release from the promoter, to be replaced by the Tet-On transactivator.
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Features

  • Reduced basal expression when combined with 1st generation Tet-On System
  • Active suppression of transcription when bound to TRE promoters
  • Binds in the absence ofdoxycycline

Additional Information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.


 
Products
Cat. # Product Contents Size Price License Units Select
631011 pTet-tTS Vector 20 ug $431.00 License Statements *
 
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.

 
 

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