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Inducible Systems

Products >  Inducible_Systems >  Inducible_Protein_Stabilization >  Viral

ProteoTuner Lentivirus & Retrovirus Systems

Analyzing protein function is a key focus in cell biology research. Clontech’s lentiviral and retroviral ProteoTuner systems make it possible to investigate the function of a specific protein of interest directly—by rapidly changing the abundance of the protein itself.

Protein Regulation Mechanism

These systems utilize a ligand-dependent destabilization domain (DD) modified from the DD of FKBP12 (1), and the ligand Shield1 to reversibly stabilize and destabilize a DD-tagged protein of interest in a predictable and dose-dependent manner. Your protein of interest is fused to a DD tag and rapidly stabilized by adding Shield1 ligand to the culture medium.

N or C Terminal Fusions to Your Protein

Most of the proteins that Clontech has tested show a better destabilization profile when the DD tag is fused to the N-terminus of the protein of interest (Systems N). Specific DD tag mutants for C-terminal tagging are available as well (Systems C); however they have a slightly reduced destabilization activity in the absence of the Shield1 ligand.

  At-A-Glance   Documents   Images & Data   Resources


  • On-demand, reversible, and tunable regulation of your favorite protein


  1. Banaszynski, L.A. et al. (2006) Cell 126(5):995–1004.

Additional Information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

Cat. # Product Contents Size Price License Units Select
631074 Lenti-X™ ProteoTuner™ Shield System C Each $740.00 License Statements
632173 Lenti-X™ ProteoTuner™ Shield System N Each $740.00 License Statements
632175 Lenti-X™ ProteoTuner™ Shield System N (w/ ZsGreen1) Each $740.00 License Statements *
632171 Retro-X™ ProteoTuner™ Shield System N Each $740.00 License Statements
632167 Retro-X™ ProteoTuner™ Shield System N (w/ ZsGreen1) Each $740.00 License Statements *
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact


Required Products
Cat. # Product Contents Size Price # of Units Select
632189 Shield1 500 uL $350.00



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