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Inducible Systems

Products >  Inducible_Systems >  Inducible_Protein_Stabilization >  Shield1_Guard1

Shield1 Ligand

ProteoTuner inducible protein stabilization systems utilize ligand-dependent destabilization domains (DD) and the Shield1 ligand to reversibly stabilize and destabilize a DD-tagged protein of interest in a predictable and dose-dependent manner. The destabilization domain of the ProteoTuner Shield System was modified from the DD of FKBP12 (1).

Shield1 Ligand

Shield1 stabilizes proteins tagged with a mutated FKBP destabilization domain (DD). It is used to protect DD-tagged proteins from proteasomal degradation. The amount of Shield1 can be varied to tune the amount of your stabilized protein of interest within the cell.

  At-A-Glance   Documents   Images & Data   Resources


  • Membrane permeable small molecule
  • Binds specifically to the DD degron, to inactivate protein degradation
  • No toxic effect on cells
  • Can be used in cells and in animal models


  • Rapid stabilization of proteins containing the DD tag
  • In vitro protein function studies
  • In vivo protein function studies


  1. Banaszynski, L.A. et al. (2006) Cell 126(5):995–1004.

Additional Information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

Cat. # Product Contents Size Price License Units Select
632188 Shield1 5 mg $1,900.00 License Statements
632189 Shield1 500 uL $350.00 License Statements



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