Human mTOR-associated protein, LST8 homolog (mLST8) is a subunit of two protein complexes that associate with mammalian target of rapamycin (mTOR), known as mTORC1 and mTORC2. Both complexes regulate cell growth and survival in response to nutrient and hormonal signals. Within mTORC1, mLST8 interacts directly with and enhances the kinase activity of mTOR. In nutrient-poor conditions, mLST8 stabilizes the interaction between mTOR and regulatory-associated protein of mTOR (RAPTOR). The MLST8 gene is conserved over a wide range of species, from yeast to human. mLST8 is also known as Gable (GBL), GbetaL, mammalian lethal with SEC13 protein 8, TORC subunit LST8, target of rapamycin complex subunit LST8, G protein beta subunit-like, POP3, and WAT1.
This product is an affinity-purified IgG antibody that recognizes human mLST8 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunoprecipitation (IP) of human mLST8 protein.