Rapamycin-insensitive companion of mTOR (Rictor) is encoded by the RICTOR gene in humans. Rictor shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae. It is involved in the control of the mammalian target of rapamycin (mTOR) and is a subunit of mTORC2. mTORC2 is activated by growth factors but, unlike mTORC1, the complex is insensitive to nutrient levels. Rictor interacts with mTOR kinase to modulate the phosphorylation of protein Kinase C alpha (PKC alpha) and the actin cytoskeleton. Rictor is also known as RPTOR independent companion of MTOR, complex 2; PIA, KIAA1999, AVO3 homolog, hAVO3, AVO3, MGC39830, and TORC2-specific protein AVO3.
This product is an affinity-purified IgG antibody that recognizes human Rictor protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection or immunoprecipitation (IP) of human Rictor protein.