Ras homolog enriched in brain (Rheb) is a member of the small GTPase superfamily of proteins and is encoded by the RHEB gene in humans. Rheb is a lipid-anchored, cell-membrane protein that contains five repeats of the RAS-related GTP-binding region. It alternates between GDP- and GTP-bound forms; post-translational modification by addition of a farnesyl group is required for this activity. Rheb is an essential component of the insulin/TOR/S6K signaling pathway that regulates cell cycle progression and cell growth. Rheb activates mammalian target of rapamycin (mTOR) kinase within the mTORC1 complex. Rheb is also known as GTP-binding protein Rheb and RHEB2.
This product is an affinity-purified IgG antibody that recognizes human Rheb protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection or immunoprecipitation (IP) of human Rheb protein.